{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:35:34Z","timestamp":1764102934680,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,3]],"date-time":"2018-06-03T00:00:00Z","timestamp":1527984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although hematological indices cannot in entirety be used to diagnose diseases or defects, the appropriate interpretation of these indices could complement diagnostics such as microscopy and serology for numerous illnesses in children. This study sought to evaluate distinct hematological indices characterizing different childhood illnesses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Full blood counts from 150 children (age range from 1 to 15\u00a0year) presenting different disease conditions at the Tamale Central Hospital were assessed. The hematological indices were compared between disease categories, and relationships between disease indicators were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of the diagnosed childhood illness were: 50.7% malaria, 20.0% diarrhea, 13.3% typhoid fever, 10.0% Sickle Cell Disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>), and 6.0% malaria\u2010typhoid co\u2010infection. Fever was diagnosed in a majority (66.0%) of the children, but was independent of each disease group, (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u20099.18,<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.057). Of the 24 hematological indices analyzed, eight; red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001), hemoglobin (Hb) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001), mean cell volume (<jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.002), mean cell hemoglobin (<jats:styled-content style=\"fixed-case\">MCH<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001; lowest and below normal range for<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>), red cell distribution width (<jats:styled-content style=\"fixed-case\">RDW<\/jats:styled-content>_<jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001), eosinophil percentage [<jats:styled-content style=\"fixed-case\">EOS<\/jats:styled-content>(%)] (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.001), eosinophil number [<jats:styled-content style=\"fixed-case\">EOS<\/jats:styled-content>#] (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.002), and platelets (<jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.001; lowest for malaria) differed significantly across the different disease groups. Levels of Hb and\/or<jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content>were below the normal reference ranges for most of the diagnosed diseases. In addition, low<jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">MCH<\/jats:styled-content>were respectively distinct for children with malaria and<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hematological indices including Hb,<jats:styled-content style=\"fixed-case\">MCV<\/jats:styled-content>and<jats:styled-content style=\"fixed-case\">PLT<\/jats:styled-content>, or<jats:styled-content style=\"fixed-case\">MCH<\/jats:styled-content>may be useful indices that could incite further diagnostic tests for malaria or<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>among children in Ghana.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22582","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T12:31:34Z","timestamp":1528115494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of hematological indices of childhood illnesses in Tamale Metropolis of Ghana"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1459-2559","authenticated-orcid":false,"given":"Nsoh Godwin","family":"Anabire","sequence":"first","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Medicine School of Medicine and Health Sciences University for development studies Tamale Ghana"},{"name":"West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) University of Ghana Accra Ghana"},{"name":"Department of Biochemistry, Cell &amp; Molecular Biology University of Ghana Accra Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Armah","family":"Aryee","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences School of Allied Health Sciences University for Development Studies Tamale Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Addo","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry &amp; Biochemistry University for Development Studies Navrongo Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Anaba","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Medicine School of Medicine and Health Sciences University for development studies Tamale Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osman Nabayire","family":"Kanwugu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Medicine School of Medicine and Health Sciences University for development studies Tamale Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Ankrah","sequence":"additional","affiliation":[{"name":"Department of Hematology Tamale Central Hospital Tamale Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon Akanzuwine","family":"Awandare","sequence":"additional","affiliation":[{"name":"West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) University of Ghana Accra Ghana"},{"name":"Department of Biochemistry, Cell &amp; Molecular Biology University of Ghana Accra Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1468-301X","authenticated-orcid":false,"given":"Gideon Kofi","family":"Helegbe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Medicine School of Medicine and Health Sciences University for development studies Tamale Ghana"},{"name":"West African Centre for Cell Biology of Infectious Pathogens (WACCBIP) University of Ghana Accra Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,3]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_5_2_1","DOI":"10.30875\/2a7c3a9e-en"},{"volume-title":"Wintrobe\u2019s Clinical Hematology","year":"2009","author":"Wintrobe MM","key":"e_1_2_5_3_1"},{"doi-asserted-by":"publisher","key":"e_1_2_5_4_1","DOI":"10.3109\/00365519609088595"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1375\/twin.2.4.250","article-title":"Genetic and environmental causes of variation in basal levels of blood cells","volume":"2","author":"Evans DM","year":"1999","journal-title":"Twin Res Hum Genet"},{"key":"e_1_2_5_6_1","first-page":"250","article-title":"Comparative study of hematological values of school children of both sexes at Dead Sea level and at 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