{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:26:53Z","timestamp":1774992413519,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Objective<\/jats:title>To investigate consistency of lymphocyte immunophenotype between labial gland and peripheral blood in patients with primary Sjogren's syndrome (pSS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventy\u2010one pSS<\/jats:styled-content> patients and 35 patients with maxillofacial trauma were included in the study. Based on the ratio of CD<\/jats:styled-content>20 to CD<\/jats:styled-content>3 in labial gland from 71 pSS<\/jats:styled-content> patients, they were divided into the high and (n\u00a0=\u00a048) and low CD<\/jats:styled-content>20 expression group (n\u00a0=\u00a023). Lymphocyte immunophenotypes in labial glands, course of disease, erythrocyte sedimentation rate (ESR<\/jats:styled-content>), C\u2010reactive protein, immunoglobulin, and complement levels were analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>In the labial gland, the levels of IgG, IgA, IgM, and C3c were higher, but C1q was lower in the pSS<\/jats:styled-content> group than in the control group (all P<\/jats:italic>\u00a0<\u00a0.05). CD<\/jats:styled-content>20 was detected in labial gland samples of all pSS<\/jats:styled-content> patients, in which CD<\/jats:styled-content>3 was positive in 66 (93.0%) patients, and negative in 5 (7.0%). The plasma levels of IgG, IgA, IgM, and CRP<\/jats:styled-content>, and ESR<\/jats:styled-content> were higher, but serum C4 level was lower in pSS<\/jats:styled-content> patients than in the control group (all P<\/jats:italic>\u00a0<\u00a0.01). Serum IgG level, ESR<\/jats:styled-content>, and labial gland CD<\/jats:styled-content>20 were higher in the high CD<\/jats:styled-content>20 expression group than the low expression group (all P<\/jats:italic>\u00a0<\u00a0.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Primary Sjogren's syndrome patients had a higher expression of CD<\/jats:styled-content>20 positive infiltrating lymphocytes of the labial gland, accompanied with the changes of immunoglobulins, and complements in both the labial gland and peripheral blood.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22585","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T06:51:44Z","timestamp":1529477504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Immunophenotypes and clinical features of lymphocytes in the labial gland of primary Sjogren's syndrome patients"],"prefix":"10.1002","volume":"32","author":[{"given":"Wenwen","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonghong","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8602-0912","authenticated-orcid":false,"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Tianjin Medical University General Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"274","article-title":"A community\u2010based cohort of 201 consecutive patients with primary Sjogren's syndrome in Israel: Ashkenazi patients compared with those of Sephardic descent","volume":"24","author":"Friedman JA","year":"2006","journal-title":"Clin Exp 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