{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:10:05Z","timestamp":1771042205807,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001692","name":"Croucher Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570298"],"award-info":[{"award-number":["81570298"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270245"],"award-info":[{"award-number":["81270245"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Telomere length is a surrogate marker of biological aging. Whether telomere length predicts the risk of atrial fibrillation (AF) independently of biological aging is controversial. We conducted a cohort study to examine the relationship between telomere length and paroxysmal AF (PAF), followed by a systematic review and meta\u2010analysis of the published literature, incorporating our own data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DNA was extracted from peripheral blood. Leucocyte telomere length was measured by a real\u2010time polymerase chain reaction\u2010based method, normalized to a single copy gene, and presented as telomere\/single gene ratio (t\/s).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 100 non\u2010AF patients and 50 PAF patients (mean age: 61.0\u00a0\u00b1\u00a09.4 and 64.0\u00a0\u00b1\u00a010.7\u00a0years, respectively) were included. T\/s for subjects without AF tended to be shorter than for those with AF (0.21 [0.06\u20100.36] vs 0.28 [0.11\u20100.71], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.077). T\/s was associated with a 1.60\u2010fold increase in the risk of AF but this was not significant (95% CI: 0.988\u20102.597, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.056). Our meta\u2010analysis confirms no difference in telomere length between AF and non\u2010AF patients and t\/s was not associated with higher risk of AF in multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our prospective data showed that leucocyte telomere length was similar between AF and non\u2010AF patients but was significantly longer in male patients with PAF than those without AF in our subgroup analysis. Our meta\u2010analysis found that t\/s did not predict AF. These findings support the notion that chronological aging, but not markers of biological aging, predicts the risk of AF.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22599","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:21:07Z","timestamp":1529997667000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Leucocyte telomere length and paroxysmal atrial fibrillation: A prospective cohort study and systematic review with meta\u2010analysis"],"prefix":"10.1002","volume":"32","author":[{"given":"Nixiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin 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Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cardiovascular Diseases Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangping","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5510-1253","authenticated-orcid":false,"given":"Gary","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong  Hong Kong, SAR 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