{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T04:30:41Z","timestamp":1776659441551,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T00:00:00Z","timestamp":1530835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The role of red cell distribution width\u2010to\u2010platelet ratio (<jats:styled-content style=\"fixed-case\">RPR<\/jats:styled-content>) has not previously been mentioned in reports on patent ductus arteriosus (<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>). Our objective was to evaluate whether <jats:styled-content style=\"fixed-case\">RPR<\/jats:styled-content> would have a role in the diagnosis and\/or prediction of pharmacological closure of <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preterm infants\u2019 gestational age \u226430\u00a0weeks and \u22641500\u00a0g who were given first ibuprofen treatment in the first week of life for hemodynamically significant <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> (hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>) were included in the study. The patients were matched for gestational age, birthweight, and sex. Patients were subdivided into two groups based on the response to medical treatment (open and closed <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>). Hemogram parameters were recorded before and after medical therapy. Groups were compared with regard to demographic and clinical characteristics and for three sequential hematological parameters. <jats:styled-content style=\"fixed-case\">RPR<\/jats:styled-content> was calculated. Patients with sepsis, anemia, perinatal asphyxia, and congenital\/chromosomal anomaly were not included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 112 infants had medically treated hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>. Of those, ductus closed in 70 neonates (closed <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>). A total of 96 infants constituted the control group. Mean gestational age and birthweight of the patients were 28.9\u00a0\u00b1\u00a02.4\u00a0weeks and 1207\u00a0\u00b1\u00a0372\u00a0g. While <jats:styled-content style=\"fixed-case\">RPR<\/jats:styled-content> was significantly increased, <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> was lower in both hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> and open <jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content> groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 and <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, respectively). In multivariate analysis, high <jats:styled-content style=\"fixed-case\">RPR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.3, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.438\u20105.872, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and <jats:styled-content style=\"fixed-case\">RDS<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.9, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.903\u20104.811, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) were detected as independent risk factors for hs<jats:styled-content style=\"fixed-case\">PDA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Red cell distribution width\u2010to\u2010platelet ratio and <jats:styled-content style=\"fixed-case\">PCT<\/jats:styled-content> may be promising supportive tools for the diagnosis and prediction of pharmacotherapy success.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22616","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T07:58:36Z","timestamp":1530863916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A promising, novel index in the diagnosis and follow\u2010up of patent ductus arteriosus: Red cell distribution width\u2010to\u2010platelet ratio"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0397-1369","authenticated-orcid":false,"given":"Buse","family":"\u00d6zer Bekmez","sequence":"first","affiliation":[{"name":"Division of Neonatology Zekai Tahir Burak Women's Health Education and Research Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00fcneyt","family":"Tayman","sequence":"additional","affiliation":[{"name":"Division of Neonatology Zekai Tahir Burak Women's Health Education and 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