{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:07:14Z","timestamp":1779394034235,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004266","name":"Consiliului National al Cercetarii Stiintifice din Invatamantul Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The patients with antiphospholipid syndrome (<jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>) associate an increased risk of atherosclerosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the predictors of an abnormal ankle\u2010brachial index (<jats:styled-content style=\"fixed-case\">ABI<\/jats:styled-content>), surrogate measure of atherosclerosis, in patients with <jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ABI<\/jats:styled-content> was measured according to standard recommendations in 106 patients. Traditional cardiovascular risk factors were assessed in all cases. A large spectrum of <jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content> antibodies was determined in 73 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 106 patients diagnosed with <jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content> were included. 28.3% patients included were found to have low <jats:styled-content style=\"fixed-case\">ABI<\/jats:styled-content>. Anti\u2010beta 2\u2010glycoprotein I (a\u03b22<jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content>) IgG antibodies [4.00 (1.00\u201079.00) vs 3.00 (0.00\u201029.00)\u00a0U\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00.02] and antiprothrombin (<jats:styled-content style=\"fixed-case\">aPT<\/jats:styled-content>) IgM antibodies [4.50 (0.00\u201082.00) vs 3.00 (0.00\u201014.00)\u00a0U\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00.05] titers were found to be higher in patients with abnormal <jats:styled-content style=\"fixed-case\">ABI<\/jats:styled-content>. However, after multivariate regression analysis, only the a\u03b22<jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content> IgG titer remained predictor of low <jats:styled-content style=\"fixed-case\">ABI<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>a\u03b22<jats:styled-content style=\"fixed-case\">GPI<\/jats:styled-content> IgG associated with impaired <jats:styled-content style=\"fixed-case\">ABI<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>. This relation might reflect their involvement in the atherosclerosis occurrence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22617","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T05:39:21Z","timestamp":1531287561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impaired ankle\u2010brachial index in antiphospholipid syndrome: Beyond the traditional risk factors"],"prefix":"10.1002","volume":"33","author":[{"given":"Simona","family":"Caraiola","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Carol Davila University of Medicine and Pharmacy  Bucharest Romania"},{"name":"Department of Internal Medicine Colentina Clinical Hospital  Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Jurcut","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dr Carol Davila Central University 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