{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T22:33:11Z","timestamp":1766788391757,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The association between gene polymorphisms and the risk of primary nephrotic syndrome (<jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content>) is uncovering recently. This study aims to investigate the relationship between single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) on <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQA<\/jats:styled-content>1<\/jats:italic> gene and the risk of <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we genotyped eight single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in the <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQA<\/jats:styled-content>1<\/jats:italic> gene in 501 <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> patients and 532 healthy people in Chinese population. Then we analyzed associations of these <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s with the clinical features in primary nephrotic syndrome of children in Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant associations with <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> were found on missense <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> rs1129740 (<jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> vs <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>, odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u00a0=\u00a01.987, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>)\u00a0=\u00a01.468\u20102.652, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.00177049) and rs1047992 (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> vs <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OR<\/jats:styled-content>\u00a0=\u00a01.857, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.325\u20102.391, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.1073E\u201010) of the <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQA<\/jats:styled-content>1<\/jats:italic> gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This work suggests <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQA<\/jats:styled-content>1<\/jats:italic> are risk factors for <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content> in Chinese population, which implies roles of immune response in the pathogenesis of <jats:styled-content style=\"fixed-case\">PNS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22623","type":"journal-article","created":{"date-parts":[[2018,7,14]],"date-time":"2018-07-14T05:16:48Z","timestamp":1531545408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of <i><scp>HLA<\/scp>\u2010<scp>DQA<\/scp>1<\/i> gene polymorphisms with the risk of children primary nephrotic syndrome in Chinese population"],"prefix":"10.1002","volume":"33","author":[{"given":"Bingbing","family":"Zhu","sequence":"first","affiliation":[{"name":"Xuzhou Children's Hospital  Xuzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-9228","authenticated-orcid":false,"given":"Ruifeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital  Xuzhou Jiangsu 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