{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:10:41Z","timestamp":1792080641350,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T00:00:00Z","timestamp":1532044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Background<\/jats:title>\n \n To investigate auditory and vestibular functions, estrogen levels, and its clinical correlation in postmenopausal females with Meniere's disease (\n MD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively analyzed the serum estradiol (E2) levels and the auditory and vestibular functions measured by auditory brainstem response (\n ABR<\/jats:styled-content>\n ) to high click rate, pure\u2010tone audiometry (\n PTA<\/jats:styled-content>\n ), and caloric test on postmenopausal women who suffered from\n MD<\/jats:styled-content>\n or not at the Specialist Clinic of Vertigo, Shandong Provincial Hospital, during September 2010 to October 2014.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 76 postmenopausal patients with\n MD<\/jats:styled-content>\n and 50 healthy postmenopausal controls were included. The patients with\n MD<\/jats:styled-content>\n had lower estrogen levels (22.50\u00a0\u00b1\u00a016.66\u00a0pg\/\n mL<\/jats:styled-content>\n vs 30.69\u00a0\u00b1\u00a018.59\u00a0pg\/\n mL<\/jats:styled-content>\n ,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.011), longer I\u2010V interpeak latency of\n ABR<\/jats:styled-content>\n (left 0.22\u00a0\u00b1\u00a00.16\u00a0mseconds vs 0.18\u00a0\u00b1\u00a00.10\u00a0mseconds,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.118; right 0.24\u00a0\u00b1\u00a00.13\u00a0mseconds vs 0.17\u00a0\u00b1\u00a00.09\u00a0mseconds,\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.001), and higher unilateral weakness (\n UW<\/jats:styled-content>\n ) value (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001) in comparison with the controls. The mean pure\u2010tone thresholds of at the speech frequency (500\u00a0Hz, 1\n kH<\/jats:styled-content>\n z, 2\n kH<\/jats:styled-content>\n z, and 3\n kH<\/jats:styled-content>\n z) were significantly elevated in patients with\n MD<\/jats:styled-content>\n than those in the controls (left\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001, right\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.01). The estradiol level of patients with\n MD<\/jats:styled-content>\n was correlated with\n ABR<\/jats:styled-content>\n latency (left\n r\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n \u22120.229,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05; right\n r\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n \u22120.220,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05) and\n UW<\/jats:styled-content>\n value (\n r\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n \u22120.328,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05), but not with mean pure\u2010tone threshold.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Estrogen levels correlated with auditory and vestibular function in postmenopausal patients with\n MD<\/jats:styled-content>\n . Low estrogen may be involved in the microcirculatory disturbance of the inner ear, affecting the occurrence and development of\n MD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jcla.22626","type":"journal-article","created":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T02:19:37Z","timestamp":1532139577000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Correlation between auditory\u2010vestibular functions and estrogen levels in postmenopausal patients with Meniere's disease"],"prefix":"10.1002","volume":"33","author":[{"given":"Huirong","family":"Jian","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naifen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8742-9536","authenticated-orcid":false,"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Shandong Provincial Hospital Affiliated to Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61161-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/VES-150549"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000089413"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989411000306"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2011.01.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-5-200003070-00002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100003947"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(01)00280-5"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016480903016570"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1210\/endo.142.11.8547","article-title":"Minireview: 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