{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:20:39Z","timestamp":1762899639535,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T00:00:00Z","timestamp":1534032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Shanghai Pujiang Young Rheumatologists Training Program","award":["SPROG201707"],"award-info":[{"award-number":["SPROG201707"]}]},{"name":"Clinical Science Innovation Program of Shanghai Shenkang Hospital Development Center","award":["SHDC1207129"],"award-info":[{"award-number":["SHDC1207129"]}]},{"name":"Shanghai Municipal Commission of Health and Family Planning, Key developing disciplines","award":["2015ZB0501"],"award-info":[{"award-number":["2015ZB0501"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"Objective<\/jats:title>This study aimed to investigate the correlation of serum uric acid (SUA<\/jats:styled-content>) with risk and dilatation diameter of ascending aortic dilatation (AAD<\/jats:styled-content>) in Beh\u00e7et's disease (BD<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seventeen BD<\/jats:styled-content> patients complicated with AAD<\/jats:styled-content> and 20 BD<\/jats:styled-content> patients without AAD<\/jats:styled-content> were consecutively enrolled and categorized into AAD<\/jats:styled-content> group and control group, respectively. Ascending aortic dilatation was determined by two\u2010dimensional doppler echocardiographic examination, and AAD<\/jats:styled-content> was defined as a diameter of ascending aorta \u22653.8 and <4.4\u00a0cm. SUA<\/jats:styled-content> was detected by quantitative immunoassay method.<\/jats:p><\/jats:sec>Results<\/jats:title>Ascending aortic dilatation patients presented with higher proportion of male patients (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.003), hypertension occurrence (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.036) and increased diameter of ascending aorta (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) compared to controls. SUA<\/jats:styled-content> was elevated in AAD<\/jats:styled-content> patients compared to controls (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.002), and receiver operating characteristic curve displayed that SUA<\/jats:styled-content> presented with great predictive value for AAD<\/jats:styled-content> risk in BD<\/jats:styled-content> patients with area under curve (AUC<\/jats:styled-content>) 0.821 (95% CI<\/jats:styled-content> 0.675\u20100.966). Pearson's analysis also disclosed that SUA<\/jats:styled-content> was positively correlated with ascending aortic diameter in total BD<\/jats:styled-content> patients. However, no difference of CRP<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.219) or ESR<\/jats:styled-content> (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.320) between AAD<\/jats:styled-content> patients and controls was observed, and no correlation of CRP<\/jats:styled-content> (R<\/jats:italic>\u00a0=\u00a0\u22120.150, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.377) or ESR<\/jats:styled-content> (R<\/jats:italic>\u00a0=\u00a00.067, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.692) with ascending aortic diameter in total BD<\/jats:styled-content> patients was discovered either. Further multivariate logistic regression illuminated that SUA<\/jats:styled-content> was an independent factor predicting AAD<\/jats:styled-content> risk in BD<\/jats:styled-content> patients (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.031).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Serum uric acid could be served as an independent marker for increased risk and severity of AAD<\/jats:styled-content> in BD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22637","type":"journal-article","created":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T02:10:27Z","timestamp":1534126227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum uric acid could be served as an independent marker for increased risk and severity of ascending aortic dilatation in Beh\u00e7et's disease patients"],"prefix":"10.1002","volume":"33","author":[{"given":"Jianfei","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital affiliated with Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinjia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Ultrasound Huadong Hospital affiliated with Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital affiliated with Fudan University Shanghai China"},{"name":"Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital affiliated with Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital affiliated with Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital affiliated with Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huafang","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital affiliated with Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Huadong Hospital affiliated with Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingfen","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology 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