{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T22:10:13Z","timestamp":1775167813032,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Gaziosmanpasa University Scientific Research Projects Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Leiomyoma, one of the most common benign tumors, causes morbidity during the reproductive years in women. The molecular pathogenesis of the disease is not clear. Leiomyomas are hormone\u2010sensitive tumors affecting around 20%\u201025% of women. Gene polymorphism studies could be important and explaining in the evaluation of multifactorial diseases such as leiomyoma. Polymorphisms involving genes responsible for the synthesis and signalization of steroid hormones could be used as genetic markers for hormone\u2010related conditions. The purpose of this study was to analyze the effect of <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1\u2010351 <jats:italic>XbaI<\/jats:italic> A\/G, <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1\u2010397 <jats:italic>Pvu<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content><\/jats:italic> T\/C, and progesterone receptor (<jats:styled-content style=\"fixed-case\">PGR<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">PROGINS<\/jats:styled-content> polymorphisms on the development of leiomyomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>In this study, 213 samples (103 leiomyoma patients and 110 healthy controls) participated. The <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1\u2010351 <jats:italic>XbaI<\/jats:italic> A\/G and <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1\u2010397 <jats:italic>Pvu<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content><\/jats:italic> T\/C gene polymorphisms were analyzed using <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> method. <jats:styled-content style=\"fixed-case\">PGR PROGINS<\/jats:styled-content> polymorphism was analyzed by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> method with specific primers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The genotype distribution and allele frequency of the <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1\u2010351 <jats:italic>XbaI<\/jats:italic> A\/G, <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1\u2010397 <jats:italic>Pvu<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content><\/jats:italic> T\/C, and <jats:styled-content style=\"fixed-case\">PGR PROGINS<\/jats:styled-content> polymorphisms were not statistically different between leiomyoma patient and control groups (p\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study reflects that <jats:styled-content style=\"fixed-case\">ER<\/jats:styled-content>\u03b1 and <jats:styled-content style=\"fixed-case\">PGR PROGINS<\/jats:styled-content> polymorphisms may not be one of the many genetic factors for leiomyoma susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22704","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T06:58:38Z","timestamp":1541228318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Analysis of estrogen and progesterone receptor gene polymorphisms in leiomyoma"],"prefix":"10.1002","volume":"33","author":[{"given":"Muhammed","family":"Toprak","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Obstetrics and Gynecology Gaziosmanpasa University Tokat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omer","family":"Ates","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Biology Gaziosmanpasa University Tokat Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asker Zeki","family":"Ozsoy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine 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