{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:51Z","timestamp":1753869411604,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Our aim intended to determine the relationship between hematological parameters (neutrophil\u2010to\u2010lymphocyte ratio [NLR], platelet\u2010to\u2010lymphocyte ratio [PLR], and eosinophil\u2010to\u2010lymphocyte ratio [ELR]) and ancylostomiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>There were 140 patients with ancylostomiasis and 159 healthy controls enrolled in this study. All data were collected from electronic medical records of the First Affiliated Hospital of Guangxi Medical University.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of NLR, PLR, and ELR in ancylostomiasis patients were significantly higher than those in the healthy controls (all <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000). A receiver operating characteristic curve was generated to assess the diagnostic efficacy of these three hematological parameters. ELR (AUC\u00a0=\u00a00.850; sensitivity\u00a0=\u00a075.00%; specificity\u00a0=\u00a086.80%) showed the superior AUC than those of NLR (AUC\u00a0=\u00a00.718; sensitivity\u00a0=\u00a053.57%; specificity\u00a0=\u00a088.68%) and PLR (AUC\u00a0=\u00a00.806; sensitivity\u00a0=\u00a068.57%; specificity\u00a0=\u00a086.79%), respectively. A multivariate regression model using the two selected indices (RBC and ELR) was established with the model's sensitivity and specificity reached 82.86% and 96.23%, respectively. In the ancylostomiasis patient group, NLR (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.452, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000) and PLR (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.357, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.000) were reversely associated with eosinophils.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pretreatment levels of the three hematological parameters (NLR, PLR, and ELR) may serve as valuable indicators for distinguishing patients with ancylostomiasis from healthy controls. NLR and PLR are negatively associated with the previous indicator, eosinophils.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22705","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T06:57:24Z","timestamp":1541228244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation between hematological parameters and ancylostomiasis: A retrospective study"],"prefix":"10.1002","volume":"33","author":[{"given":"Zuojian","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine First Affiliated Hospital of Guangxi Medical University Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine First Affiliated Hospital of Guangxi Medical University Nanning 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