{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:48Z","timestamp":1753869408568,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Human papillomavirus (HPV) infection can lead to the development of cervical cancer. This study assessed the genotype distribution of HPV of high\u2010grade squamous intraepithelial lesion (HSIL) and invasive cervical cancer (ICC) in Ganzhou population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 935 females who got HPV testing from January 2016 to July 2018 in the maternal and child health hospital of Ganzhou were enrolled in the study, including 806 HSIL and 129 ICC. HPV detection and genotyping were tested by HPV Geno\u2010Array test kit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall HPV\u2010positive rate was 74.0% in Ganzhou. Among the HSIL and ICC patients, the positive rates of HPV detection were 75.6% and 64.3%. Among the HSIL individuals, the most prevalent hr\u2010HPV genotype was HPV 16. And the 4 common subtypes in decreasing order were HPV 52, 58, 33, and 18. Of the ICC patients, the most frequently hr\u2010HPV subtype was HPV 16 followed by 18, 52, 58, and 59. Among the squamous cell carcinoma (SCC) patients, for hr\u2010HPV genotypes, HPV 16, 18, 52, 58, and 59 were five most common subtypes. In patients with adenocarcinoma (ADC), the most common hr\u2010HPV genotype was HPV 18, followed by HPV 16, 52, 56, 68, 73. And, we found U\u2010shaped and S\u2010shaped curves in the HPV distribution of different age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence and distribution of HPV genotypes in Ganzhou differed from other regions of China and Western countries. These results can serve as valuable reference for HPV vaccination programs for Ganzhou women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22708","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T06:56:10Z","timestamp":1541228170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and distribution of human papillomavirus genotypes among women with high\u2010grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China"],"prefix":"10.1002","volume":"33","author":[{"given":"Linhong","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Pathology, School of Basic Medical Sciences Southern Medical University Guangzhou China"},{"name":"Department of Pathology Maternal and child health hospital of Ganzhou City Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of emergency People's hospital of Ganzhou City Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fansheng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pathology Maternal and child health hospital of Ganzhou City Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Sciences Southern Medical University Guangzhou China"},{"name":"Department of Pathology, Nanfang Hospital, Southern Medical University\/The First School of Clinical Medicine Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5265-8459","authenticated-orcid":false,"given":"Yanqing","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medical Sciences Southern Medical University Guangzhou China"},{"name":"Department of Pathology, Nanfang Hospital, Southern Medical University\/The First School of Clinical Medicine Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_9_4_1","first-page":"358","volume":"374","author":"Women\u2019s health in rural China","year":"2009","journal-title":"Lancet"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60022-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28607"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.07.067"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S169822"},{"key":"e_1_2_9_9_1","first-page":"1","article-title":"Working group on the evaluation of carcinogenic risks to humans. 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