{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:35:39Z","timestamp":1792319739033,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T00:00:00Z","timestamp":1542758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background\/Aims<\/jats:title><jats:p>Today, invasive diagnostic tests are necessary for definite diagnosis of adult celiac disease (CD). However, in selected children patients, the need for invasive tests is ceased. In this study, we evaluated adult patients according to the ESPGHAN (European Pediatric Gastroenterology Hepatology and Nutrition Society) criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010nine patients (aged 17\u201066) with symptoms of CD were included. Serum samples were tested for total IgA, tTG\u2010IgA (antitissue transglutaminase), tTG\u2010IgG, DGP\u2010IgA (antideamidated gliadin peptide), DGP\u2010IgG, and EMA (endomysial antibodies). HLA\u2010DQ typing was studied with PCR\u2010SSP (sequence\u2010specific primers) method. Biopsy samples were evaluated according to Marsh scoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In CD patients, 71.4% (15\/21) of the patients were diagnosed without biopsy according to the EPSGHAN criteria but when ESPGHAN's IgA tTG threshold value for children was taken into consideration (&gt;200\u00a0IU\/mL), the sensitivity decreased to 81%. Celiac disease diagnosed and control groups were compared in terms of HLA tissue types. DQ2.5 homozygous or DQ2.5\/DQ2.2 was significantly higher in CD group, and DQ2\u2010 or DQ8\u2010negative HLA tissue type was significantly higher in control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When serological tests, HLA typing, and clinical symptoms are all in favor of CD, biopsy may not be performed in selected adult CD patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22722","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T14:47:08Z","timestamp":1542811628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of non\u2010invasive tests with invasive tests in the diagnosis of celiac disease"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7877-5960","authenticated-orcid":false,"given":"Yasemin Derya","family":"G\u00fclseren","sequence":"first","affiliation":[{"name":"Department of Microbiology, Ankara Training and Research Hospital Health Sciences University Alt\u0131nda\u011f Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9434-1049","authenticated-orcid":false,"given":"Ali Kudret","family":"Adilo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ankara Training and Research Hospital Health Sciences University Alt\u0131nda\u011f Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-8538","authenticated-orcid":false,"given":"Mihriban","family":"Y\u00fccel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ankara Training and Research Hospital Health Sciences University Alt\u0131nda\u011f Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3052-5225","authenticated-orcid":false,"given":"Zuhal","family":"Da\u011f","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ankara Training and Research Hospital Health Sciences University Alt\u0131nda\u011f Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-3338","authenticated-orcid":false,"given":"Nilnur","family":"Eyerci","sequence":"additional","affiliation":[{"name":"Department of Tissue Typing Laboratory, Ankara D\u0131\u015fkap\u0131 Y\u0131ld\u0131r\u0131m Beyaz\u0131t Training and Research Hospital Health Sciences University Etlik Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7035-4723","authenticated-orcid":false,"given":"Rukiye","family":"Berkem","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ankara Training and Research Hospital Health Sciences University Alt\u0131nda\u011f Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3140-7458","authenticated-orcid":false,"given":"Levent","family":"Filik","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ankara Training and Research Hospital Health Sciences University Alt\u0131nda\u011f Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-288X","authenticated-orcid":false,"given":"Muzaffer","family":"\u00c7aydere","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ankara Training and Research Hospital Health Sciences University Alt\u0131nda\u011f Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.131"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03502.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01977.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.04.004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0058-0"},{"key":"e_1_2_5_8_1","first-page":"191","article-title":"Frequencies of HLA\u2010DQ2 and HLA\u2010DQ8 haplotypes in Czech and Slovak coeliac patients and the healthy population","volume":"61","author":"Wroblova K","year":"2014","journal-title":"Biochima Polonica"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05471.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"e_1_2_5_12_1","unstructured":"WGO Practice Guideline.Celiac Disease. 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