{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:41:15Z","timestamp":1791934875077,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T00:00:00Z","timestamp":1551052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Urinalysis is one of the most frequently ordered diagnostic laboratory tests. In order to reduce workload and costs, rapid screening tests such as urine test strip analyses are applied. The aim of this study was to evaluate the analytical performance of the UC\u20103500 as well as the diagnostic performance in comparison with reference methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>We measured within\u2010run and between\u2010run imprecision based on quantitative reflectance values. 347 prospectively included urine specimens were investigated for the presence of glucose, protein, albumin, leukocyte esterase, and hemoglobin peroxidase activity, and ordinal scale results were compared to an automated urine particle analyzer (UF\u20105000, Sysmex, Kobe, Japan) and wet chemistry (Roche Cobas 8000, Mannheim, Germany).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Within\u2010run and between\u2010run imprecision results based on reflectance data for both the 9 and 11 parameter test strips ranged from 0.07% to 1.36% for the low\u2010level control and from 0.37% to 6.13% for the high\u2010level control, depending on the parameter. Regarding diagnostic performance, the sensitivity\/specificity for glucose, protein, albumin, leukocyte esterase, and hemoglobin peroxidase was 100\/60%, 94.2\/88.2%, 81.8\/89.2%, 81.7\/92.8%, and 85.1\/88.6%, respectively; the negative predictive value was 100%, 83.3%, 89.1%, 94.6%, and 96.1%. The Spearman correlation coefficients of the UC\u20103500 vs reference methods ranged from 0.915 to 0.967, depending on the parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This fully automated urine test strip analyzer overall shows a satisfying performance and can reliably screen out negative urine samples in order to focus on further characterization of positive samples in the following steps of the workflow.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22870","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T06:26:22Z","timestamp":1551162382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Semiquantitative, fully automated urine test strip analysis"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-0679","authenticated-orcid":false,"given":"Matthijs","family":"Oyaert","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Ghent University Hospital Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris R.","family":"Delanghe","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ghent University Hospital Gent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2010.038"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Scand","volume":"231","author":"European Urinalysis Guidelines","year":"2000","journal-title":"J Clin Lab Invest Suppl"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2019.39.1.15"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(00)00256-4"},{"key":"e_1_2_7_6_1","first-page":"533","article-title":"Evaluation of a urine chemistry analyser","volume":"13","author":"Rowell DM","year":"1998","journal-title":"Prof Nurse"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.05.032"},{"key":"e_1_2_7_8_1","first-page":"53","article-title":"Microalbuminuria in diabetic patients: a longitudinal study","volume":"242","author":"Svendsen PA","year":"1981","journal-title":"Acta Endocrinol Suppl (Copenh)"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00365.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(03)00826-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.06.017"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2017-1159"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2017.07.028"},{"key":"e_1_2_7_14_1","first-page":"261","article-title":"Measurement of proteins with the behring nephelometer. 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