{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:12:15Z","timestamp":1774264335615,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T00:00:00Z","timestamp":1553558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770475"],"award-info":[{"award-number":["81770475"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association of gene polymorphisms of angiotensinogen (AGT), the key factor in rennin\u2010angiotensin\u2010aldosterone system (RAAS), with high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) and coronary artery disease (CAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current study recruited the patients who were hospitalized and assessed by coronary angiography for suspected CAD. The patients with documented CAD served as CAD group (n\u00a0=\u00a0492) while the patients without documented CAD (n\u00a0=\u00a087) served as control group. We compared laboratory data and CAD risk factors between the two groups. Furthermore, we analyzed the association of AGT M235T, G217A, G152A, G\u20106A, A\u201020C genotypes with coronary artery stenosis and in\u2010stent restenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significantly differences between two patient groups in sex, smoking history, diabetes mellitus, carotid atherosclerosis, lower limb arteriosclerosis, hs\u2010CRP, blood glucose, and the level of high\u2010density lipoprotein (HDL; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In CAD group, hs\u2010CRP levels increased with increasing number of coronary artery branches (1, 2, or \u22653; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and Gensini integral was positively correlated with hs\u2010CRP levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.361, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Frequencies of genotype and allele distribution in individual angiotensinogen loci (M235T, G217A, G152A, G\u20106A, A\u201020C) did not differ in two patient groups. Following stratification of patients according to hs\u2010CRP levels (&lt;1\u00a0mg\/L, 1\u20103\u00a0mg\/L, and &gt;3\u00a0mg\/L), the distribution frequency of allele M235T was statistically different among the groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In CAD patients, M235T among several AGT gene polymorphisms is associated with elevated hs\u2010CRP levels with AGT C allele as the significant factor for patients with hs\u2010CRP level of more than 1\u00a0mg\/L.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22881","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T15:02:59Z","timestamp":1553612579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The relationship among angiotensinogen genes polymorphisms and hs\u2010CRP and coronary artery disease"],"prefix":"10.1002","volume":"33","author":[{"given":"Min","family":"Zhu","sequence":"first","affiliation":[{"name":"Laboratory of Cardiovascular Disease Taizhou Hospital Wenzhou Medical University Taizhou China"},{"name":"Enze Medical Research Center Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9168-3553","authenticated-orcid":false,"given":"Jiangbo","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Disease Taizhou Hospital Wenzhou Medical University Taizhou China"},{"name":"Department of Cardiology Taizhou Hospital Wenzhou Medical University Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Enze Medical Research Center Taizhou 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Stanford University School of Medicine Stanford USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Disease Taizhou Hospital Wenzhou Medical University Taizhou China"},{"name":"Enze Medical Research Center Taizhou China"},{"name":"Department of Cardiology Taizhou Hospital Wenzhou Medical University Taizhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of Cardiovascular Disease Taizhou Hospital Wenzhou Medical University Taizhou China"},{"name":"Department of Cardiology Taizhou Hospital Wenzhou Medical University Taizhou 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