{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:23:13Z","timestamp":1772234593964,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of our study was to assess potential correlations between serum galectin\u20103 concentrations and Ankylosing Spondylitis Disease Activity (ASDAS) index in patients with ankylosing spondylitis (AS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 112 patients with AS were included, and 130 healthy subjects were considered as controls. We collected the detailed medical history, and ASDAS index was used to assess the disease severity in patients with AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum galectin concentrations were higher in AS patients compared to the health groups (14.1\u00a0\u00b1\u00a09.6 vs 9.2\u00a0\u00b1\u00a03.7, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The correlation analysis showed that serum galectin concentrations were significantly positively correlated with C\u2010reactive protein and erythrocyte sedimentation rate (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.369, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001; <jats:italic>r<\/jats:italic>\u00a0=\u00a00.240, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011). In addition, the positively correlation of serum galectin\u20103 with global pain index (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.238, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011) was observed in AS patients. A significant positively correlation between serum galectin and ASDAS index in AS patients was found (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.367; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In multiple linear regression analysis, the results indicated that increased serum galectin still was correlated with ASDAS index (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.322, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in patients with AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum galectin concentrations were found to be correlated with ASDAS index in patients with AS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22914","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T09:05:29Z","timestamp":1558343129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum galectin\u20103 concentrations in patients with ankylosing spondylitis"],"prefix":"10.1002","volume":"33","author":[{"given":"Ming\u2010Yu","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Joint Surgery Sixth Affiliated Hospital of Xinjiang Medical University \u00dcr\u00fcmqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traumatic Orthopaedics Sixth Affiliated Hospital of Xinjiang Medical University \u00dcr\u00fcmqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Liang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Sixth Affiliated Hospital of Xinjiang Medical University \u00dcr\u00fcmqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-2711","authenticated-orcid":false,"given":"Ya\u2010Bin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery The Second Hospital of Nanjing Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-3285-4.10070-1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-1328-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200107000-00007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-016-1489-x"},{"key":"e_1_2_6_7_1","first-page":"202","article-title":"Th1\/Th2 balances and ankylosing spondylitis","volume":"4","author":"Zhu J","year":"2000","journal-title":"Chin J Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp097"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-015-0230-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-013-0032-y"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:GLYC.0000014083.48508.6a"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.12.140"},{"issue":"4","key":"e_1_2_6_13_1","first-page":"S41","article-title":"galectin\u20103 and galectin\u20103 binding protein levels in Beh\u00e7et\u2019s disease and their association with disease activity","volume":"25","author":"Lee YJ","year":"2007","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11287"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/24.3.242"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3814-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.053"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511167103"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-0965OC"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203315580146"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30118"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.2.1167"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24574"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201106-0965OC"},{"issue":"8","key":"e_1_2_6_25_1","first-page":"1914","article-title":"Expression of galectins\u20101 and \u20103 correlates with defective mononuclear cell apoptosis in patients with juvenile idiopathic arthritis","volume":"28","author":"Harjacek M","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308094361"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.22914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.22914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.22914","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.22914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:08:45Z","timestamp":1694282925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.22914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,20]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1002\/jcla.22914"],"URL":"https:\/\/doi.org\/10.1002\/jcla.22914","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,20]]},"assertion":[{"value":"2019-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e22914"}}