{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T17:30:52Z","timestamp":1786815052011,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies have shown that many genes that regulate cell migration are associated with susceptibility to recurrent miscarriage. Terminal differentiation\u2010induced non\u2010coding RNA (TINCR) regulates the migration and invasion of a variety of tumor cells and is associated with susceptibility to various diseases. However, whether the lncRNA TINCR polymorphism is associated with susceptibility to recurrent miscarriage is unclear. Therefore, we investigated the relationship between the rs2288947 A\u00a0&gt;\u00a0G polymorphism of the lncRNA TINCR and susceptibility to recurrent abortion. We recruited 248 recurrent spontaneous abortion patients and 392 healthy control subjects from the Southern Chinese population and used the TaqMan method for genotyping. There was no evidence that this polymorphism is associated with recurrent miscarriage (AG vs AA: adjusted OR\u00a0=\u00a00.904, 95% CI\u00a0=\u00a00.647\u20101.264, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.5552; GG and AA: adjusted OR\u00a0=\u00a00.871, 95% CI\u00a0=\u00a00.475\u20101.597, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.6542; dominant model: AG\/GG vs AA: adjusted OR\u00a0=\u00a00.898, 95% CI\u00a0=\u00a00.653\u20101.236, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.5101; and recessive model: GG vs AA\/AG: adjusted OR\u00a0=\u00a00.910, 95% CI\u00a0=\u00a00.505\u20101.639, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.7527). The stratified analysis also showed no significant associations. This study suggests that the rs2288947 A\u00a0&gt;\u00a0G polymorphism of the lncRNA TINCR may not be associated with recurrent miscarriage in a Southern Chinese population. A larger multicenter study is needed to confirm our conclusions.<\/jats:p>","DOI":"10.1002\/jcla.22919","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T04:10:05Z","timestamp":1558671005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between the rs2288947 polymorphism of the lncRNA <i>TINCR<\/i> gene and the risk of recurrent miscarriage in a Southern Chinese population"],"prefix":"10.1002","volume":"33","author":[{"given":"Wendong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Maoming People's Hospital Maoming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huazhong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Pi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LanYan","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Prenatal Diagnosis Maoming People's Hospital Maoming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0209-6961","authenticated-orcid":false,"given":"Di","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Blood Transfusion, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"},{"name":"Department of Clinical Laboratory, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.10.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.10.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012561"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012754"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-018-0917-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-017-0311-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114781"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-016-1599-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.18"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11661"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4161\/rna.26249"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4255-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20170301"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7559"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.01.049"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.205"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S170526"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.12.077"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16538"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13513"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2008.00601.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.11.001"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12275"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.25081"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.06.028"}],"container-title":["Journal 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