{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:42:12Z","timestamp":1791416532610,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T00:00:00Z","timestamp":1564185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune thyroid disease (AITD) is a common organ\u2010specific autoimmune disorder, and genetic, environmental, and endogenous factors are responsible for initiation of thyroid autoimmunity. Some AITD patients suffer from a certain degree of glucose\u2010lipid metabolism disorder. This study aims to explore the changes in glucose\u2010lipid metabolism, insulin resistance, and inflammatory factors in patients with AITD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 91 patients with Hashimoto's thyroiditis were retrospectively analyzed and divided into hypothyroidism group (n\u00a0=\u00a042) and normal thyroid group (n\u00a0=\u00a049), while 50 healthy people were selected as control group. The changes in glucose\u2010lipid metabolism, insulin resistance, and inflammatory factors in each group were compared, and their correlations with the thyroid function were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The levels of serum interleukin\u20106 (IL\u20106), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), IL\u201012, IL\u201010, (FINS), and homeostasis model assessment of insulin resistance (HOMA\u2010IR) were gradually declined in sequence of hypothyroidism group, normal thyroid group, and control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In hypothyroidism group, the levels of serum\u2010free triiodothyronine (FT3), free thyroxine (FT4), (TC), triglyceride (TG), and low\u2010density lipoprotein cholesterol (LDL\u2010C) were significantly lower than those in normal thyroid group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), while the level of serum thyroid stimulating hormone (TSH) was significantly higher than that in normal thyroid group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). However, the fasting blood glucose and 2\u2010hour postprandial blood glucose levels had no statistically significant differences among the three groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Autoimmune thyroid disease patients are prone to fat metabolism\u00a0disorder, and the serum thyroid hormone level has a close correlation with blood lipid metabolism, insulin metabolism, and inflammatory factors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.22929","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T08:39:36Z","timestamp":1564216776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Changes in glucose\u2010lipid metabolism, insulin resistance, and inflammatory factors in patients with autoimmune thyroid disease"],"prefix":"10.1002","volume":"33","author":[{"given":"Yi","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism The Affiliated Hospital of Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Affiliated Hospital of Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Affiliated Hospital of Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Affiliated Hospital of Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2279-971X","authenticated-orcid":false,"given":"Qin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism The Affiliated Hospital of Southwest Medical University Luzhou Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,27]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"32","article-title":"Regulatory B and T cell responses in patients with autoimmune thyroid disease and healthy controls","volume":"63","author":"Kristensen B","year":"2016","journal-title":"Dan Med 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