{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:48:01Z","timestamp":1776088081309,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To analyze the therapeutic effect of high\u2010frequency ultrasound (HFU)\u2010assisted dye laser on hemangioma patients and changes in serum hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 20 patients diagnosed with hemangioma in our hospital from January 2013 to March 2018 were selected, including 12 males and eight females. All patients were treated with HFU\u2010assisted dye laser. The site and type of hemangioma and age distribution of patients were collected, and changes in data and area of hemangioma and serum HIF\u20101\u03b1 before and after treatment were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The vascular condition of hemangioma in all patients was significantly improved at 7, 14, and 30\u00a0days after treatment. Gray\u2010scale ultrasound displayed that the tumor area was reduced by more than 50%. After treatment, the serum HIF\u20101\u03b1 level declined obviously after treatment compared with that before treatment, showing a statistically significant difference (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HFU\u2010assisted dye laser can effectively reduce the tumor area, decrease the serum HIF\u20101\u03b1 level, and improve the prognosis in the treatment of hemangioma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.22970","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T01:23:51Z","timestamp":1569893031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic effect of high\u2010frequency ultrasound\u2010assisted dye laser on hemangioma and its influence on serum HIF\u20101\u03b1 in patients"],"prefix":"10.1002","volume":"34","author":[{"given":"Hongzhang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-7443","authenticated-orcid":false,"given":"Jianhua","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography, Affiliated Hangzhou First People\u2019s Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01558.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2012.04.020"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000007"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2010.07.008"},{"issue":"12","key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1097\/00042728-200412010-00007","article-title":"Thickness of healthy and affected skin of children with port wine stains: potential repercussions on response to pulsed dye laser treatment","volume":"30","author":"Nagore E","year":"2004","journal-title":"Dermatol Surg"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.141321"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijp.2346"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2012.08.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2011.02155.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2014.09.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145824"},{"issue":"4","key":"e_1_2_6_13_1","first-page":"754","article-title":"Biomicroscopy in patients with unilateral pseudoexfoliation. 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