{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:23:09Z","timestamp":1788438189596,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T00:00:00Z","timestamp":1565481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C1731 and HI16C0992"],"award-info":[{"award-number":["HI14C1731 and HI16C0992"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), and monocyte\u2010to\u2010lymphocyte ratio (MLR) are indicators of systemic inflammation and are useful as markers in systemic rheumatic diseases. In this study, we compared the NLR, PLR, and MLR among patients with polymyalgia rheumatica (PMR) and rheumatoid arthritis (RA), and explored possible associations with clinical features, disease activity, and prognosis in patients with PMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study enrolled 94 patients with PMR and 242 patients with RA who were initially diagnosed at the rheumatology clinic of a university\u2010based tertiary hospital. Symptoms, physical examination, and medical histories were collected with the results of laboratory tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neutrophil\u2010to\u2010lymphocyte ratio (4.5\u00a0\u00b1\u00a03.3 vs 2.8\u00a0\u00b1\u00a01.8), PLR (222.7\u00a0\u00b1\u00a0115.5 vs 159.7\u00a0\u00b1\u00a078.1), and MLR (0.4\u00a0\u00b1\u00a00.3 vs 0.3\u00a0\u00b1\u00a00.2) were higher in patients with PMR compared with patients with RA (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). NLR, PLR, and MLR were correlated with specific laboratory values, including CRP and albumin, in patients with PMR. After disease activity resolved, NLR (2.95\u00a0\u00b1\u00a02.32, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), PLR (137.5\u00a0\u00b1\u00a082.3, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and MLR (0.26\u00a0\u00b1\u00a00.16, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) decreased significantly. By comparing patients according to the disease course, swollen joint counts were higher in the chronic course group compared with the remission group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), while the NLR, PLR, and MLR were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neutrophil\u2010to\u2010lymphocyte ratio, platelet\u2010to\u2010lymphocyte ratio, and monocyte\u2010to\u2010lymphocyte ratio levels were associated with disease activity and specific clinical features, although they could not predict prognosis in patients with PMR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23000","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T03:44:03Z","timestamp":1565581443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Neutrophil\u2010to\u2010lymphocyte ratio and platelet\u2010to\u2010lymphocyte ratio are associated with disease activity in polymyalgia rheumatica"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7313-0795","authenticated-orcid":false,"given":"Ju\u2010Yang","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Rheumatology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Ajou University School of Medicine Suwon Korea"},{"name":"Office of Biostatistics Ajou Research Institute for Innovative Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-393X","authenticated-orcid":false,"given":"Chang\u2010Hee","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2609-3367","authenticated-orcid":false,"given":"Hyoun\u2010Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213883"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2018.33.e241"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31825-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13343"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/AITC201705020"},{"issue":"114","key":"e_1_2_7_7_1","first-page":"86","article-title":"Use of contrast\u2010enhanced magnetic resonance imaging of the pelvis to describe changes at different anatomic sites which are potentially specific for polymyalgia rheumatica","volume":"36","author":"Fruth M","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex376"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.131055"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes294"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.103663"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu526"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27728"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3874-3"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23320"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13460"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5444"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159447"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13037"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12582"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.04.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13400"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2019.39.4.345"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21908"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.5.434"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.2.168"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181704"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.26669"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.03.055"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1993.1302099.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2004.00863.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.019638"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1979.hed1901014.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13328"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.177220"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23000","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T03:54:01Z","timestamp":1694231641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,11]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/jcla.23000"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23000","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,11]]},"assertion":[{"value":"2019-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23000"}}