{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:29:13Z","timestamp":1790036953481,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2016\u2010I2M\u20101\u2010018"],"award-info":[{"award-number":["2016\u2010I2M\u20101\u2010018"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>\n                      To prevent\n                      <jats:italic>Treponema Pallidum<\/jats:italic>\n                      (TP) transmission from blood transfusion, enzyme\u2010linked immunosorbent assay (EIA) for anti\u2010TP has been widely used in routine blood donation screening in China for many years. The aim of this study was to evaluate the performance of the Abbott CMIA assay for detection of anti\u2010TP in Chinese blood donors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      A total of 2420 plasma samples, already routinely screened for anti\u2010TP by two different EIAs, from four blood Centers were tested for anti\u2010TP by Abbott CMIA. Subsequently, all samples with positive results by one or both EIAs and\/or by Abbott CMIA were subjected to confirmatory testing (CT) using recombinant immunoblot assay (RIBA) or\n                      <jats:italic>Treponema Pallidum<\/jats:italic>\n                      particle agglutination assay (TPPA). TP infection was defined by a RIBA or TPPA positive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with two EIAs strategy, Abbott CMIA showed a relatively best sensitivity as 98.80% (95% CI: 97.44%\u2010100.16%) and a relatively best specificity as 99.58% (95% CI: 99.30%\u201099.85%), yielding the best consistency (99.49%) between anti\u2010TP CT results with the highest\n                      <jats:italic>\u03ba<\/jats:italic>\n                      value of .98.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first study to evaluate the performance of the Abbott CMIA assays for detection of syphilis in Chinese blood donors. Our results suggested that CMIA performed better than both EIAs, and implementation of CMIA replacing two different EIA reagents might help to further reduce the risk of transfusion\u2010transmitted TP infection, decrease unnecessary blood waste and loss of blood donors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23033","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T05:57:02Z","timestamp":1571205422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluate performance of the Abbott chemiluminescent microparticle immunoassay assay for detection of syphilis infection in Chinese blood donors"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-1814","authenticated-orcid":false,"given":"Ping","family":"Fu","sequence":"first","affiliation":[{"name":"Institute of Blood Transfusion Chinese Academy of Medical Sciences &amp; Peking Union Medical College Chengdu China"},{"name":"Sichuan Blood Safety and Blood Substitute International Science and Technology Cooperation Base Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil","family":"Devare","sequence":"additional","affiliation":[{"name":"Abbott Diagnostics Lake Forest IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Abbott Diagnostics Shanghai R&amp;D Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010ting","family":"Lv","sequence":"additional","affiliation":[{"name":"Abbott Diagnostics Shanghai R&amp;D Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yin","sequence":"additional","affiliation":[{"name":"Abbott Diagnostics Shanghai R&amp;D Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing\u2010ting","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion Chinese Academy of Medical Sciences &amp; Peking Union Medical College Chengdu China"},{"name":"Sichuan Blood Safety and Blood Substitute International Science and Technology Cooperation Base Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ke","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion Chinese Academy of Medical Sciences &amp; Peking Union Medical College Chengdu China"},{"name":"Sichuan Blood Safety and Blood Substitute International Science and Technology Cooperation Base Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion Chinese Academy of Medical Sciences &amp; Peking Union Medical College Chengdu China"},{"name":"Sichuan Blood Safety and Blood Substitute International Science and Technology Cooperation Base Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Shan","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Service Stanford University Medical Center Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02544-15"},{"issue":"5","key":"e_1_2_8_3_1","first-page":"433","article-title":"Syphilis: a reemerging infection","volume":"86","author":"Mattei PL","year":"2012","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01461.x"},{"key":"e_1_2_8_5_1","unstructured":"World Health Organization.Screening donated blood for transfusion\u2010transmissible infections 2010. 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