{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:37:59Z","timestamp":1790656679538,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This work aimed to evaluate oxidative stress in chronic myeloid leukemia (CML) patients treated with tunisian (IM) vs controls and in CML patients with resistance to IM vs patients without resistance to IM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included 40 CML patients and 34 controls. Of 40 patients with CML, 26 patients were developed in resistance to IM. The oxidant\/antioxidant markers were evaluated by spectrophotometric methods for all used samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For CML patients, increased malondialdehyde (MDA) and advanced oxidation protein products (AOPP) levels were found compared to controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01). Higher catalase (CAT) activity (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.048) and lower superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities, reduced Glutathione (GSH) and vitamin C levels were found in CML patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The comparison between the resistant vs no\u2010resistant CML patients revealed higher MDA level (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.02) and CAT and SOD activities in IM\u2010resistant patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03). GPx activity was reduced (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04). Furthermore, increased mean ratio of MDA\/GSH, MDA\/GPx, and SOD\/(GPx\u00a0+\u00a0CAT) was found in IM\u2010resistant patients as compared with no\u2010resistant (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.035). The mean ratio of GPx\/GSH in the IM\u2010resistant CML patients was lower than in IM no\u2010resistant one (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.039). For IM\u2010resistant patients,\u00a0we found negative correlation between MDA level and the ratio SOD\/(CAT\u00a0+\u00a0GPx) (\n                      <jats:italic>r\u00a0<\/jats:italic>\n                      =\u00a0\u22120.46,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002); and positive correlation between SOD and (CAT\u00a0+\u00a0GPx) activities (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.38,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.06) and\u00a0between GSH level and GPx activity (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.53,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our results have shown a highly disturbed oxidative profile in IM\u2010resistant CML patients as compared to no\u2010resistant. The H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      has a key role in the resistance to IM treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23050","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T04:35:10Z","timestamp":1571200510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-6837","authenticated-orcid":false,"given":"Mariam","family":"Ammar","sequence":"first","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine University of Sfax Sfax Tunisia"},{"name":"Faculty of Sciences of Sfax University of Sfax Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-9720","authenticated-orcid":false,"given":"Lobna","family":"Ben Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine University of Sfax Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moez","family":"Medhaffar","sequence":"additional","affiliation":[{"name":"Department of Hematology Hedi Chaker Hospital University of Sfax Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanen","family":"Ghozzi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine University of Sfax Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zouheir","family":"Sahnoun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine University of Sfax Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Hakim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine University of Sfax Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7462-4305","authenticated-orcid":false,"given":"Malek","family":"Mseddi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine University of Sfax Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moez","family":"Elloumi","sequence":"additional","affiliation":[{"name":"Department of Hematology Hedi Chaker Hospital University of Sfax Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Zeghal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Medicine University of Sfax Sfax Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25011"},{"key":"e_1_2_7_3_1","first-page":"4267","article-title":"Oxidative stress\u2010induced apoptosis in chronic myelogenous leukemia K562 cells by an active compound from the dithio carbamate family","volume":"17","author":"Khoshtabiat L","year":"2016","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.74"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062867"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.38"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2015_1189"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra013339"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms160818111"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021924"},{"key":"e_1_2_7_11_1","first-page":"03.006","article-title":"Use of second\u2010 and third\u2010generation tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia: an evolving treatment paradigm","author":"Jabbour E","year":"2015","journal-title":"Clin. 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