{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:52:37Z","timestamp":1780613557548,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T00:00:00Z","timestamp":1573084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute coronary syndrome (ACS) is the leading cause of death in developing and developed countries, yet assessing the risk of its development remains challenging. Several lines of evidence indicate that small, dense low\u2010density lipoproteins (sd\u2010LDL) are associated with increased cardiovascular disease risk. We aim to evaluate sd\u2010LDL concentration for predicting the risk of ACS in Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline characteristics of 121 patients with ACS and 172 healthy controls were obtained. Plasma sd\u2010LDL\u2010C was measured using homogeneous assay, and the proportion of sd\u2010LDL\u2010C in LDL\u2010C was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was gender and age effect on the sd\u2010LDL\u2010C concentration and sd\u2010LDL\u2010C\/LDL\u2010C ratio among healthy subjects. Elevated sd\u2010LDL\u2010C concentrations and sd\u2010LDL\u2010C\/LDL\u2010C ratio were observed in ACS patients with unstable angina pectoris (UAP), non\u2013ST\u2010segment elevation myocardial infarction (STEMI), and ST\u2010segment elevation myocardial infarction (NSTEMI) compared with healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05); however, there were no differences among ACS groups. According to Pearson's correlation coefficient analyses, sd\u2010LDL\u2010C concentration and sd\u2010LDL\u2010C\/LDL\u2010C ratio were positively correlated with triglyceride (TG) and LDL\u2010C concentrations (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) and negatively correlated with high\u2010density lipoprotein (HDL) concentration (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Based on the receiver operating characteristic (ROC) curves, the cutoff values of sd\u2010LDL\u2010C and sd\u2010LDL\u2010C\/LDL\u2010C ratio for the prediction of ACS were 1.06\u00a0mmol\/L and 34.55%, respectively. Multivariate logistic regression analysis demonstrated that the sd\u2010LDL\u2010C\/LDL\u2010C ratio, but not sd\u2010LDL\u2010C concentration, was significantly associated with ACS events [OR (95% CI): 1.24, 1.11\u20101.38, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The sd\u2010LDL\u2010C\/LDL\u2010C ratio may be associated with an increased risk of developing ACS in Chinese population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23085","type":"journal-article","created":{"date-parts":[[2019,11,7]],"date-time":"2019-11-07T05:53:13Z","timestamp":1573105993000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of small dense low\u2010density lipoprotein concentration for predicting the risk of acute coronary syndrome in Chinese population"],"prefix":"10.1002","volume":"34","author":[{"given":"Bin","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Guangzhou First People's Hospital The Second Affiliated Hospital of South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwu","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Laboratory Science Affiliated Cancer Hospital &amp; Institute of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Anhui Provincial Hospital The First Affiliated Hospital of University of Science and Technology of China Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Guangzhou First 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