{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:19:48Z","timestamp":1771615188173,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Glaucoma is the irreversible vision loss and contributes second leading cause of blindness worldwide. Matrix metalloproteinase\u20109 (MMP\u20109) is involved with remodeling and destruction of extracellular matrix. Elevated MMP\u20109 levels and various functional variants of MMP\u20109 have been associated with glaucoma in different population. In the current investigation, we tested association of MMP\u20109 common variants with different clinical categories of glaucoma in Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We enrolled total of 396 glaucoma patients those reported to hospital comprising of 212 primary angle closure glaucoma (PACG) cases and 184 primary open\u2010angle glaucoma POAG patients. In addition, 329 normal individuals from similar geographical areas were enrolled as healthy controls. Five common single nucleotide polymorphisms (rs3918242, rs3918254, rs2250889, rs3918249, and rs17576) were genotyped by PCR\u2010RFLP. Plasma levels of MMP\u20109 were quantified by ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Heterozygotes (GC) and allele \u201cG\u201d for rs2250889 polymorphism were more frequent in PACG cases compared with healthy controls (GC: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001, OR\u00a0=\u00a02.26; G: <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001, OR\u00a0=\u00a01.19). Similarly, heterozygous mutant and minor allele for rs3918242 polymorphism were more prevalent in POAG in comparison with healthy controls. Interestingly, distribution of rs17576 variant was statistically higher in both PACG and POAG cases than healthy controls. Furthermore, analysis of plasma MMP\u20109 with MMP\u20109 polymorphisms revealed significant association of rs2250889, rs3918242, and rs17576 with plasma levels of the protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MMP\u20109 mutants are associated with elevated plasma MMP\u20109 and predisposed to development of glaucoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23105","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T05:39:01Z","timestamp":1573537141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["RETRACTED: Role of matrix metalloproteinase\u20109 gene polymorphisms in glaucoma: A hospital\u2010based study in Chinese patients"],"prefix":"10.1002","volume":"34","author":[{"given":"Fengqiong","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Nanchong Central Hospital Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongshan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Nanchong Central Hospital Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9382-2991","authenticated-orcid":false,"given":"Xuewen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Nanchong Central Hospital Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.07.020705"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0365"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2125"},{"issue":"1","key":"e_1_2_6_6_1","first-page":"172","article-title":"Expression of matrix metalloproteinases and inhibitor by human trabecular meshwork","volume":"32","author":"Alexander JP","year":"1991","journal-title":"Invest Ophthalmol Vis 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