{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:47:47Z","timestamp":1776088067259,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T00:00:00Z","timestamp":1579910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T00:00:00Z","timestamp":1579910400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Recently, the rs5370 single nucleotide polymorphisms (SNPs) of\n                      <jats:italic>Endothelin\u20101<\/jats:italic>\n                      (\n                      <jats:italic>EDN1)<\/jats:italic>\n                      showed association with the susceptibility of childhood primary nephrotic syndrome (CPNS). This study aims to investigate potential relationships between other\n                      <jats:italic>EDN1<\/jats:italic>\n                      SNPs and CPNS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seven SNPs (rs5370, rs10478723, rs1476046, rs1800541, rs2070698, rs2071942, and rs9296344) of the\n                      <jats:italic>EDN1<\/jats:italic>\n                      gene were genotyped in 579 CPNS patients and 586 age\u2010matched healthy children. Then, we analyzed potential associations of the six SNPs with susceptibility of CPNS by using rs5370 as a conditional variant in a logistic regression model. SNP\u2010SNP interaction analysis was performed to investigate the joint effects of the seven SNPs in the pathogenesis of CPNS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Independent with rs5370, only rs9296344 significantly associated (T vs C, odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.57\u20100.88,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) with the susceptibility of CPNS. Meanwhile, no joint effect among the analyzed seven SNPs was discovered in this study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study discovered that C allele of rs9296344 on\n                      <jats:italic>EDN1<\/jats:italic>\n                      is a novel independent risk factor for CPNS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23134","type":"journal-article","created":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T12:39:12Z","timestamp":1579955952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endothelin\u20101 rs9296344 associates with the susceptibility of childhood primary nephrotic syndrome"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2916-7889","authenticated-orcid":false,"given":"Ruifeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huandan","family":"Yang","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingbing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Yuan","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Peng","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Lv","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suqin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaowen","family":"Zhong","sequence":"additional","affiliation":[{"name":"Xuzhou Children's Hospital Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2018.08.006"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.18.0098"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2017.09.005"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2017.1374003"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.04.010"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12930"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S131869"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.06.022"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000185"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.15171\/jnp.2017.24"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108103"},{"issue":"2","key":"e_1_2_5_13_1","first-page":"220","article-title":"Single nucleotide polymorphisms (SNPs): functional implications of regulatory\u2010SNP (rSNP) and structural RNA (srSNPs) in complex diseases","volume":"149","author":"Ramirez\u2010Bello J","year":"2013","journal-title":"Gac Med Mex"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21865"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.22175"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S167578"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6978"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.4155\/fsoa-2018-0031"},{"issue":"6262","key":"e_1_2_5_19_1","first-page":"S74","article-title":"Drug discovery in traditional Chinese medicine: from herbal fufang to combinatory drugs","volume":"350","author":"He B","year":"2015","journal-title":"Science"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.11.023"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2017.02.006"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.23134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:50:42Z","timestamp":1776084642000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,25]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/jcla.23134"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23134","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,25]]},"assertion":[{"value":"2019-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23134"}}