{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:48:01Z","timestamp":1776088081281,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Science and Technology Development Research Project of Shaanxi Province-Key Problems of Science and Technology in Social Development","award":["2016SF-034"],"award-info":[{"award-number":["2016SF-034"]}]},{"name":"National Natural Science Foundation of China-Youth Projects","award":["81500272"],"award-info":[{"award-number":["81500272"]}]},{"name":"National Natural Science Foundation of China-Youth Projects","award":["81600356"],"award-info":[{"award-number":["81600356"]}]},{"name":"National Natural Science Foundation of China-Youth Projects","award":["81702733"],"award-info":[{"award-number":["81702733"]}]},{"name":"National Natural Science Foundation of China-Youth Projects","award":["81601816"],"award-info":[{"award-number":["81601816"]}]},{"DOI":"10.13039\/501100001809","name":"Program for the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81670229"],"award-info":[{"award-number":["81670229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Program for the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81570210"],"award-info":[{"award-number":["81570210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Program for the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81670229"],"award-info":[{"award-number":["81670229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"Program for the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81570210"],"award-info":[{"award-number":["81570210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bethune-Merck Diabetes Research Fund"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Adiponectin (APN) circulates as high\u2010molecular weight (HMW), medium\u2010molecular weight (MMW), and low\u2010molecular weight (LMW) forms. Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. Currently, the role of LMW, MMW, and HMW APN remains largely unclear in NAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined the variation of these forms and analyzed the related clinical characteristics in NAFLD. A total of 63 male NAFLD patients (mean age: 43.00\u00a0\u00b1\u00a06.10\u00a0years) and 70 healthy male subjects (mean age: 42.53\u00a0\u00b1\u00a07.98\u00a0years) were included in the study. Total APN and other clinical characteristics were measured. The changes in HMW, MMW, and LMW APN were determined in NAFLD patients and NAFLD patients on a high\u2010fat diet, and the association between the groups was further analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Decreased levels of total APN and three APN isoforms were found in NAFLD. Significantly decreased levels of HMW (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) and MMW (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) were observed in NAFLD of high\u2010fat diet patients. In NAFLD patients, height (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u2212.270,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.032) and N\u2010epsilon\u2010(carboxymethyl) lysine (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u2212.259,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.040) significantly correlated with total APN. HMW APN was significantly associated with fasting plasma glucose (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0.350,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.016), alanine aminotransferase (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u2212.321,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.029), and aspartate aminotransferase (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u2212.295,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.045). Additionally, MMW APN was significantly associated with total cholesterol (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0.357,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.014) and high\u2010density lipoprotein (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0.556,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001). Low\u2010density lipoprotein (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u2212.283,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.054) was also clearly associated with LMW APN in NAFLD patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that HMW and MMW APN may be involved in the pathogenesis and progression of NAFLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23148","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T04:08:10Z","timestamp":1577419690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Middle\u2010 and high\u2010molecular weight adiponectin levels in relation to nonalcoholic fatty liver disease"],"prefix":"10.1002","volume":"34","author":[{"given":"Kun","family":"Lian","sequence":"first","affiliation":[{"name":"Department of Cardiology Xijing Hospital The Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Nan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital The Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Xijing Hospital The Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao\u2010Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Xijing Hospital The Fourth Military Medical University Xi'an 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