{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:46:12Z","timestamp":1776087972544,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T00:00:00Z","timestamp":1579824000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"the Specialized Research Fund for the Science and Technology Department of Guangdong Province","award":["2014A020212477"],"award-info":[{"award-number":["2014A020212477"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Syphilis is a sexually transmitted disease caused by\n                      <jats:italic>Treponema pallidum<\/jats:italic>\n                      (TP) infection. In recent years, diagnostic reagents with fully automated immunoassay instruments have become mainstream. However, these positive screening tests with high sensitivity, which are performed with full automation, need confirmation by\n                      <jats:italic>Treponema pallidum<\/jats:italic>\n                      particle agglutination (TPPA) to be judged as positive.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the diagnostic performance of Lumipulse G TP\u2010N assay (Lumi\u2010TP, Fujirebio Inc) in 223 preselected TP\u2010positive samples and 1041 TP\u2010negative samples, compared it with that of the TP gold standard test (TPPA) and Architect Syphilis TP test (Archi\u2010TP, Abbott).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The concordance rates for the results for the positive and negative samples between Lumi\u2010TP and TPPA were 100%. On the other hand, the rates for the results between Archi\u2010TP and TPPA were 100% for positive samples and 99.14% (1032\/1041) for negative samples. Correlation tendency and rate between Archi\u2010TP and Lumi\u2010TP were 2.549 and 0.841 in positive specimens up to 160 detected values in Lumi\u2010TP. However, the detection value of Archi\u2010TP reached a plateau when it exceeded about 40. Furthermore, according to the comparison of each value obtained from Archi\u2010TP and Lumi\u2010TP with the strength of the staining of each line in the immune\u2010chromatography assay kit, ESPLINE TP (Fujirebio Inc) for TP major antigens, Tp15\u201017 and TpN47, it was found that Lumi\u2010TP obtained higher values than Archi\u2010TP, particularly for TpN 47.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lumi\u2010TP has high specificity and is useful not only for screening but also for determining the amount of anti\u2010TP antibodies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23194","type":"journal-article","created":{"date-parts":[[2020,1,25]],"date-time":"2020-01-25T00:10:38Z","timestamp":1579911038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of \u201cLumipulse anti\u2010\n                    <i>Treponema pallidum<\/i>\n                    \u201d and \u201cArchitect Syphilis TP\u201d and further examination"],"prefix":"10.1002","volume":"34","author":[{"given":"Jianbo","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chumei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaorong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9336-8397","authenticated-orcid":false,"given":"Laisheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60074-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.643"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13237"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21765"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.8.3.534-539.2001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02869.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00116-15"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.28.8.1704-1707.1990"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.28.2.296-302.1990"},{"issue":"508","key":"e_1_2_6_11_1","first-page":"83","article-title":"Molecular analysis of the fetal IgM response to Treponema pallidum antigens: implications for improved serodiagnosis of congenital syphilis","volume":"159","author":"S\u00e1nchez PJ","year":"1989","journal-title":"J Infect Dis"},{"key":"e_1_2_6_12_1","first-page":"288","article-title":"Evaluation of an enzyme immunoassay for IgM antibodies to Treponema pallidum in syphilis in man","volume":"60","author":"Muller F","year":"1984","journal-title":"Br J Vener Dis"},{"key":"e_1_2_6_13_1","unstructured":"Japanese patent JP3831759 B2 20061011."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.3.508"}],"container-title":["Journal of Clinical Laboratory 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