{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:07:13Z","timestamp":1776089233478,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aimed to investigate the correlation of circular RNA SMARCA5 (circ\u2010SMARCA5) expression with clinicopathological characteristics and survival profiles, furthermore, to explore the function of circ\u2010SMARCA5 on regulating cell proliferation and chemotherapy sensitivity in non\u2010small cell lung cancer (NSCLC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 460 NSCLC patients were retrospectively reviewed, and circ\u2010SMARCA5 expressions in tumor tissue and adjacent tissue were detected by RT\u2010qPCR. Clinical characteristics were collected. Disease\u2010free survival (DFS) and overall survival (OS) were calculated. In vitro, circ\u2010SMARCA5 overexpression and control overexpression plasmids were transfected into NCI\u2010H1437 as well as NCI\u2010H1299 cells, which were further treated with different concentrations of cisplatin and gemcitabine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Circ\u2010SMARCA5 expression was decreased in tumor tissues compared to adjacent tissues. Moreover, circ\u2010SMARCA5 expression negatively correlated with tumor size, lymph node metastasis, and TNM stage, but positively correlated with DFS and OS. Subsequent analysis displayed that circ\u2010SMARCA5 high expression independently predicted prolonged DFS and OS. In vitro, circ\u2010SMARCA5 expression was reduced in NSCLC cell lines (NCI\u2010H650, NCI\u2010H1299, NCI\u2010H1437, and A549) compared to human normal lung bronchus epithelial cell line (BEAS\u20102B). In NCI\u2010H1437 and NCI\u2010H1299 cells, cell proliferation was decreased by circ\u2010SMARCA5 overexpression, furthermore, chemosensitivity to cisplatin and gemcitabine were enhanced in circ\u2010SMARCA5 overexpression treated cells compared to the control cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Circ\u2010SMARCA5 may serve as a tumor suppressor in NSCLC, which provides insight to the exploration of novel strategies in NSCLC management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23195","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T07:02:32Z","timestamp":1579158152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["RETRACTED: Circular RNA SMARCA5 may serve as a tumor suppressor in non\u2010small cell lung cancer"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-2859","authenticated-orcid":false,"given":"Suiju","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Pharmacy People's Hospital of Dongxihu District Wuhan City Wuhan 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of circular RNA SMARCA5\/microRNA\u2010620 axis in the regulation of cervical cancer cell proliferation, invasion and migration","volume":"22","author":"Tian JDC","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_6_16_1","unstructured":"NCCN clinical practice guidelines in oncology: non\u2010small cell lung cancer 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