{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:50:04Z","timestamp":1791265804249,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T00:00:00Z","timestamp":1578441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ19H160007"],"award-info":[{"award-number":["LQ19H160007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>In the present study, we purposed to determine serum chitinase 3\u2010like 1 (CHI3L1) expression characteristics in chronic liver diseases monoinfected with hepatitis B virus and analyze its diagnostic value in liver fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 467 chronic hepatitis B (CHB) patients, 312 liver cirrhosis (LC) patients, and 104 hepatocellular carcinoma (HCC) patients at our institution were enrolled, and clinical indicators were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our data have shown that the expression level of serum CHI3L1 was steadily increased from CHB to LC to HCC (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Serum CHI3L1 expression levels were positively associated with liver stiffness measurement (LSM), fibrosis\u20104 (FIB\u20104) index, aspartate aminotransferase\u2010to\u2010platelet ratio index (APRI), and HCC stage. The receiver operating characteristic (ROC) curve proved that serum CHI3L1 was superior to other noninvasive methods (LSM, FIB\u20104, and APRI) with an area under the ROC curve (AUC) of 0.97 in diagnosing significant fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum CHI3L1 harbors significant clinical value in chronic liver diseases infected with hepatitis B virus, especially in the diagnosis of fibrosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23200","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T01:15:51Z","timestamp":1578532551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The clinical significance of serum chitinase 3\u2010like 1 in hepatitis B\u2013related chronic liver diseases"],"prefix":"10.1002","volume":"34","author":[{"given":"Zhenluo","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Hepatology HwaMei Hospital University Of Chinese Academy Of Sciences Ningbo China"},{"name":"Department of Biochemistry and Molecular Biology Zhejiang Key Laboratory of Pathophysiology Medical School of Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology HwaMei Hospital University Of Chinese Academy Of Sciences Ningbo China"},{"name":"Department of Biochemistry and Molecular Biology Zhejiang Key Laboratory of Pathophysiology Medical School of Ningbo University Ningbo China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancheng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Zhejiang Key Laboratory of Pathophysiology 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