{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:12:07Z","timestamp":1777417927912,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302540"],"award-info":[{"award-number":["81302540"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinically, D\u2010dimer (DD) levels are mainly used to exclude diseases such as deep venous thrombosis (DVT). In clinical testing, DD assays can be subjected to interference that may cause false results, which directly affect the clinical diagnosis. Our hypothesis was that the 95% confidence intervals (CIs) of the fibrin degradation product (FDP)\/DD and fibrinogen (Fib)\/DD ratios were used to identify these false results and corrected via multiple dilutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 16\u00a0776 samples were divided into three groups according to the DD levels detected by Sysmex CS5100 and CA7000: Group A, DD\u00a0\u2265\u00a02.0\u00a0\u03bcg\/mL fibrinogen equivalent unit (FEU); group B, 0.5\u00a0&lt;\u00a0DD\u00a0&lt;\u00a02.0\u00a0\u03bcg\/mL FEU; and group C, DD\u00a0\u2264\u00a00.5\u00a0\u03bcg\/mL FEU. The 95% CIs of the FDP\/DD and Fib\/DD ratios were calculated. Six abnormal DD results were found according to the 95% CIs. For verification, we performed multiple dilutions, compared the results with those of other instruments, and tested the addition of heterophilic blocking reagent (HBR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median and 95% CI of the FDP\/DD ratio were 3.76 and 2.25\u20108.15 in group A, 5.63 and 2.86\u201010.58 in group B, 10.23 and 0.91\u201047.71 in groups C, respectively. For the Fib\/DD ratio, the 95% CIs was 0.02\u20102.21 in group A, 0.68\u20108.15 in group B, and 3.82\u201055.27 in groups C. Six abnormal results were identified after multiple dilutions, by comparison with other detection systems, and after HBR addition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The FDP\/DD ratio is more reliable for identifying false results. If the FDP\/DD ratio falls outside the 95% CI, it should be verified by different methods.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23216","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T11:33:51Z","timestamp":1579692831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of and solution for false D\u2010dimer results"],"prefix":"10.1002","volume":"34","author":[{"given":"Xian\u2010Yan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Shantou University Medical College Shantou China"},{"name":"Laboratory of Molecular Cardiology The First Affiliated Hospital of Shantou University Medical College Shantou China"},{"name":"Laboratory of Molecular Imaging the First Affiliated Hospital of Shantou University Medical College Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Xuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Shantou University Medical College Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Long","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Shantou University Medical College Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teng\u2010Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The Second Affiliated Hospital of Shantou University Medical College Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Shantou University Medical College Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u2010Ru","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Shantou University Medical College Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan\u2010Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Shantou University Medical College Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7135-1391","authenticated-orcid":false,"given":"Ying\u2010E","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Shantou University Medical College Shantou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TB01769B"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-165845"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.024"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000453"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-339-8_34"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.15407\/ubj88.02.016"},{"issue":"3","key":"e_1_2_8_8_1","first-page":"425","article-title":"D\u2010dimer test: diagnostic role in clinical and sub\u2010clinical DIC","volume":"46","author":"Saxena R","year":"2003","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04637.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12665"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmw001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.11.031"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2017.08.015"},{"key":"e_1_2_8_14_1","unstructured":"(CLSI) CaLSI.Defining establishing and verifying reference intervals in the clinical laboratory; approved guideline\u2014third edition CLSI document C28\u2013A3 (ISBN 1\u201056238\u2010682\u20104). 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