{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T19:27:51Z","timestamp":1773516471368,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["201801D121216"],"award-info":[{"award-number":["201801D121216"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blast transformation of chronic myelogenous leukemia (CML) to T lymphoblastic lymphoma\/acute lymphoblastic leukemia (T\u2010LBL\/ALL) is rare, and the molecular mechanism is still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 28\u2010year\u2010old woman who developed T\u2010ALL with coexpressing both p210 and p190 BCR\u2010ABL transcripts five years after the initial diagnosis of CML in chronic phase. The proliferation of bone marrow was extremely active with blast cells over 20%. Chromosome analysis revealed t(9;22)(q34;q11) and t(10;11)(q25;p15). Flow immunophenotyping showed that blasts expressed CD4, CD7, CD11b, CD38, CD34, CD33, and cCD3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It is the first T\u2010cell blast of CML case with coexisting p210 and p190 as well as additional chromosome translocations. Through review this case and previous reports, we will reveal that CML patients with T\u2010lymphocyte transformation depend on potential molecular and pathological mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23241","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T11:48:53Z","timestamp":1581594533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["T\u2010cell blast crisis of chronic myelogenous leukemia presented with coexisting p210 and p190 BCR\u2010ABL transcripts and t(10;11)(q11;p15)"],"prefix":"10.1002","volume":"34","author":[{"given":"Ting","family":"Xia","sequence":"first","affiliation":[{"name":"The Haematology Department The Second Hospital of Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchao","family":"Yang","sequence":"additional","affiliation":[{"name":"The Haematology Department The Second Hospital of Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxia","family":"Li","sequence":"additional","affiliation":[{"name":"The Haematology Department The Second Hospital of Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmei","family":"Chang","sequence":"additional","affiliation":[{"name":"The Haematology Department The Second Hospital of Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlan","family":"Li","sequence":"additional","affiliation":[{"name":"The Haematology Department The Second Hospital of Shanxi Medical University Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanggang","family":"Ren","sequence":"additional","affiliation":[{"name":"The Haematology Department The Second Hospital of Shanxi Medical University Taiyuan Shanxi 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