{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:49:37Z","timestamp":1778946577629,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tianjin Public Health Bureau Key Research Program","award":["2015KZ013"],"award-info":[{"award-number":["2015KZ013"]}]},{"name":"National 13th 5-Year Plan for Hepatitis Research","award":["2017ZX10203201"],"award-info":[{"award-number":["2017ZX10203201"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Spontaneous bacterial peritonitis (SBP) is one of the most critical complications of decompensated liver cirrhosis. This study aimed to assess whether ascitic neutrophil gelatinase\u2010associated lipocalin (NGAL), a reliable inflammation biomarker, can be used to detect SBP in decompensated cirrhosis patients and to predict mortality from decompensated cirrhosis\u2010related SBP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 204 hospitalized patients with ascites of decompensated liver cirrhosis and follow\u2010up of 28\u00a0days. We measured ascitic NGAL levels by the latex\u2010enhanced immunoturbidimetric method. Simultaneously, we observed the patterns of ascitic NGAL levels in the SBP group after 7\u00a0days of anti\u2010infection treatment with third\u2010generation cephalosporins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ascitic NGAL levels significantly increased in the SBP group compared with that in the non\u2010SBP group, 111(83.9, 178) ng\/mL vs 48(35.4, 63) ng\/mL<jats:italic>, P<\/jats:italic>\u00a0&lt;\u00a0.001. Likewise, the ascitic\u00a0NGAL levels of SBP were higher than non\u2010SBP with or without renal dysfunction. There was a positive relationship between ascitic NGAL and ascitic polymorphonuclear (PMN) leukocyte and a negative relationship between ascitic NGAL and ascitic albumin in the SBP group. An ascitic NGAL cutoff of 108.95\u00a0ng\/mL was used for predicting a poor prognosis for SBP patients. Ascitic NGAL and the model for end\u2010stage liver disease score were independent risk factors in decompensated liver cirrhosis patients with SBP through multivariate Cox regression. A dynamic trend of ascitic NGAL in SBP patients was consistent with the clinical prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ascitic NGAL may not only be a biomarker for monitoring SBP but also a predictor for more severe outcomes in decompensated cirrhosis\u2010related SBP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23247","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T09:24:07Z","timestamp":1582709047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The value of ascitic neutrophil gelatinase\u2010associated lipocalin in decompensated\u00a0liver cirrhosis with spontaneous bacterial peritonitis"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0729-2021","authenticated-orcid":false,"given":"Hua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hepatology The Third Central Clinical College of Tianjin Medical University Tianjin China"},{"name":"Department of Hepatology The Third Central Hospital of Tianjin Tianjin China"},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third Central Clinical College of Tianjin Medical University Tianjin China"},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Artificial Cell Engineering Technology Research Center Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caiyun","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Oncology The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China"},{"name":"Department of Oncology Henan Cancer Hospital Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third Central Hospital of Tianjin Tianjin China"},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Artificial Cell Engineering Technology Research Center Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanying","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third Central Hospital of Tianjin Tianjin China"},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Artificial Cell Engineering Technology Research Center Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Artificial Cell Engineering Technology Research Center Tianjin China"},{"name":"Department of Clinical Laboratory The Third Central Hospital of Tianjin Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoju","family":"Pang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"},{"name":"Artificial Cell Engineering Technology Research Center Tianjin China"},{"name":"Department of Clinical Laboratory The Third Central Hospital of Tianjin Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third Central Clinical College of Tianjin Medical University Tianjin China"},{"name":"Department of Hepatology The Third Central Hospital of Tianjin Tianjin China"},{"name":"Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Tianjin China"},{"name":"Tianjin Institute of Hepatobiliary Disease Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12797"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-018-09923-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82217-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26980"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26226-6"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"319","article-title":"Neutrophil gelatinase\u2010associated lipocalin for assessment of acute kidney injury in cirrhosis","volume":"70","author":"Huelin P","year":"2019","journal-title":"A prospective study. Hepatology"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.12.020"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000530"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.004"},{"issue":"2","key":"e_1_2_6_11_1","first-page":"91","article-title":"Infections in patients affected by liver cirrhosis: an update","volume":"25","author":"Ascione T","year":"2017","journal-title":"Infez Med"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.019"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.04.011"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21588"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-016-0546-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.11.035"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2019.05.013"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.912569"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1216-y"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-017-4804-7"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.07.044"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12714"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.038679"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i1.16"},{"issue":"1","key":"e_1_2_6_25_1","first-page":"12","article-title":"Early diagnosis of acute kidney injury by urinary neutrophil gelatinase associated lipocalin in adult critically Ill patients","volume":"31","author":"Shoaib M","year":"2019","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12112"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.07.001"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.02.023"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000457"},{"key":"e_1_2_6_30_1","first-page":"15","article-title":"Neutrophil Gelatinase Associated Lipocalin (NGAL) \u2010 a biomarker of renal dysfunction in patients with liver cirrhosis: do we have enough proof?","volume":"8","author":"Firu SG","year":"2015","journal-title":"J Med Life"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29290"},{"issue":"9","key":"e_1_2_6_32_1","first-page":"16434","article-title":"The diagnostic value of neutrophil gelatinase\u2010associated lipocalin and hepcidin in bacteria translocation of liver cirrhosis","volume":"8","author":"Zhang J","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27447"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27077"},{"issue":"12","key":"e_1_2_6_35_1","first-page":"1883","article-title":"Analysis of risk factors for patients with liver cirrhosis complicated with spontaneous bacterial peritonitis","volume":"47","author":"Wang Y","year":"2018","journal-title":"Iran J Public Health"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.02.027"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.23247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T14:55:11Z","timestamp":1693320911000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,26]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1002\/jcla.23247"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23247","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,26]]},"assertion":[{"value":"2019-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23247"}}