{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:14:45Z","timestamp":1792059285188,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T00:00:00Z","timestamp":1582848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To facilitate the early detection of chronic diseases, we analyzed the clinical characteristics of anti\u2010gastric parietal cell antibody (PCA)\u2010positive population, revealed the early characteristics of the population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>According to the retrospective analysis, current situation investigation and comparative analysis of the clinical characteristics and medical history of the subjects, the comparison between the groups was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>(a) The positive rate of PCA detection in department of gastroenterology in our hospital was 35.80%. Among the individuals who underwent PCA, esophagogastroduodenoscopy (EGD) and pathological examination at the same time, 33.59% of the patients with PCA positive were diagnosed as atrophic gastritis by gastroscopy, which was much higher than 9.09% of the patients with PCA negative. (b) The incidence of gastroesophageal reflux, hypertension, ischemic heart disease (IHD) and cerebral ischemia in PCA\u2010positive population were 65.45%, 81.63%, 15.43%, and 31.61%, respectively, which were significantly higher than those in the control group. (c) The incidence rates of decreased red blood cells (RBC) and increased homocysteine (HCY) in laboratory\u2010related tests were 38.30% and 69.15%, respectively, which were much higher than those in control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PCA has predictive value for a variety of chronic diseases and timely detection is of great significance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23264","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T04:19:26Z","timestamp":1582949966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of clinical characteristics of 2243 with positive anti\u2010gastric parietal cell antibody"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2614-3048","authenticated-orcid":false,"given":"Yaping","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Baoding NO.1 Central Hospital Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxia","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Baoding NO.1 Central Hospital Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-2912","authenticated-orcid":false,"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Baoding NO.1 Central Hospital Baoding China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Baoding NO.1 Central Hospital Baoding 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