{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:47:08Z","timestamp":1776088028793,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402208"],"award-info":[{"award-number":["81402208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interleukin (IL)\u201034 is a recently discovered pro\u2010inflammatory cytokine and is a vital regulator in different tumor types. However, the function of IL\u201034 in thyroid carcinoma has yet to be investigated. In this study, we analyzed the expression of IL\u201034 in human papillary thyroid cancer (PTC) samples and determined its effects on the proliferation and apoptosis of PTC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined the expression of IL\u201034 in serum and tissue samples of patients with PTC by Western blotting and ELISA assay and analyzed its association with clinicopathological features including tumor size, tumor node metastasis (TNM) stage, and lymph node metastasis (LNM). We selected TPC1 and K1 for knockdown or overexpressing of IL\u201034 via small interference RNA transfection. The proliferation of PTC cells was evaluated by CCK8 assay. We further investigated the role of IL\u201034 in apoptosis by flow cytometry and studied the protein levels of epithelial\u2010mesenchymal transition (EMT) biomarkers, phosphorylated extracellular\u2010regulated kinase (ERK), and total\u2010ERK (t\u2010ERK) by Western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results show that IL\u201034 is significantly upregulated in serum and tissue samples from patients with PTC. IL\u201034 promotes the proliferation and suppresses apoptosis in PTC cells. In addition, IL\u201034 can promote the EMT and activate ERK signaling pathway in PTC cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides novel evidence that IL\u201034 serves as an oncogene in PTC. IL\u201034 promotes proliferation, EMT phenotype, and ERK signaling pathway and inhibits apoptosis in PTC cells. Therefore, IL\u201034 may be a potent therapeutic target for the treatment of PTC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23335","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T07:20:05Z","timestamp":1592896805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["IL\u201034 is a potential biomarker for the treatment of papillary thyroid cancer"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-5916","authenticated-orcid":false,"given":"Ping","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Surgery The First Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Hospital of China Medical University Shenyang 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