{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T01:14:44Z","timestamp":1780881284206,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the tumor circular RNA_0018289 (circ_0018289) expression and its correlation with clinical characteristics as well as survival profiles in cervical cancer patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A hundred and ninety\u2010two cervical cancer patients who received surgical resection were recruited in this prospective study. Tumor tissue and paired adjacent tissue were obtained during the surgery, in which circ_0018289 expression was detected by reverse transcription quantitative polymerase chain reaction. Disease\u2010free survival (DFS) and overall survival (OS) were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Circ_0018289 expression was upregulated in tumor tissue compared with paired adjacent tissue (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), and receiver operative characteristic curve disclosed its good value for separating tumor tissue from adjacent tissue with an area under curve of 0.907 (95% CI: 0.879\u20100.935). Additionally, tumor circ_0018289 expression was positively associated with tumor size (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.009), lymph node metastasis (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005) and Federation International of Gynecology and Obstetrics stage (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005). The DFS (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005) and OS (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.015) were both worse in patients with circ_0018289 high expression compared to patients with circ_0018289 low expression. Meanwhile, in patients with circ_0018289 high expression, DFS and OS were the longest in patients with high+ expression followed by patients with high++ expression, and the shortest in patients with high+++ expression. Moreover, circ_0018289 high expression could independently predict worse DFS in the total cervical cancer patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.042).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Circ_0018289 could serve as a potential disease monitoring and prognostic biomarker in cervical cancer patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23340","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T09:06:50Z","timestamp":1587546410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289"],"prefix":"10.1002","volume":"34","author":[{"given":"Jing","family":"He","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-5195","authenticated-orcid":false,"given":"Zhen","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics The Central Hospital of Wuhan Tongji Medical College Huazhong University of Science and Technology Wuhan 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of circular RNA hsa_circ_0001038 promotes cervical cancer cell progression by acting as a ceRNA for miR\u2010337\u20103p to regulate cyclin\u2010M3 and metastasis\u2010associated in colon cancer 1 expression","volume":"144","author":"Wang Y","year":"2019","journal-title":"Gene"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109311"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29045"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.11.032"},{"issue":"5","key":"e_1_2_5_21_1","first-page":"3714","article-title":"circEIF4G2 modulates the malignant features of cervical cancer via the miR218\/HOXA1 pathway","volume":"19","author":"Mao Y","year":"2019","journal-title":"Mol Med Rep"}],"container-title":["Journal of Clinical Laboratory 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