{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:50:55Z","timestamp":1775134255914,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570212"],"award-info":[{"award-number":["81570212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31800976"],"award-info":[{"award-number":["31800976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Eosinophil levels predict prognosis in ST\u2010segment elevation myocardial infarction (STEMI) patients. Both eosinophils and high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) play a major role in the acute inflammatory response of myocardial infarction. The purpose of this study was to evaluate eosinophil percentage (EOS%) and hs\u2010CRP as prognostic markers for in\u2010hospital adverse events in STEMI patients undergoing primary percutaneous coronary intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the clinical data of 518 patients. Major adverse cardiac events (MACEs) were defined as cardiac rupture, cardiac arrest, malignant arrhythmia, and cardiac death. Based on the receiver operating characteristic (ROC) analysis, all patients were regrouped into 3 groups (None, One, and Two) according to cutoff EOS% value (\u22640.3%) and hs\u2010CRP value (&gt;11.8\u00a0mg\/L). Both Cox regression analyses and the KM (Kaplan\u2010Meier) survival curve were used to examine the prognostic role of combined hs\u2010CRP and EOS% in cardiovascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 518 STEMI patients, 50 of them developed MACEs. Patients who developed MACEs had a significantly lower EOS% and higher hs\u2010CRP than patients who remained MACE\u2010free. In the multivariable Cox regression analysis, the highest risk of in\u2010hospital MACEs was constantly observed in patients with a combined low EOS% and elevated hs\u2010CRP. Patients with reduced EOS% and high hs\u2010CRP had significantly higher incidence rates of cardiac rupture (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), cardiac arrest (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), and malignant arrhythmia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001); furthermore, they had the worst cumulative survival compared with the other two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined reduced EOS% and elevated hs\u2010CRP were valuable tools for identifying patients at risk of in\u2010hospital MACEs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23367","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T09:48:13Z","timestamp":1590140893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Combination of eosinophil percentage and high\u2010sensitivity C\u2010reactive protein predicts in\u2010hospital major adverse cardiac events in ST\u2010elevation myocardial infarction patients undergoing primary percutaneous coronary intervention"],"prefix":"10.1002","volume":"34","author":[{"given":"Liu","family":"Ye","sequence":"first","affiliation":[{"name":"The First Branch The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010mei","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Jiang","sequence":"additional","affiliation":[{"name":"The First Branch The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First 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