{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:16:43Z","timestamp":1780363003815,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) has become a worldwide public health emergency. This study aimed to investigate the clinical significance of liver blood tests in COVID\u201019 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The analysis included clinical data of 23 patients with suspected COVID\u201019 and 66 patients with confirmed COVID\u201019 from January 25 to February 20, 2020. The relationship between liver blood test results, liver condition (HBsAb positive, HBcAb positive, and fatty liver disease), and duration of hospital stay among COVID\u201019 patients was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median hospital stay of COVID\u201019 patients was 6\u00a0days. Serum albumin (Alb) level was lower in patients with COVID\u201019 confirmed on admission than in patients with suspected COVID\u201019 (40.08\u00a0g\/L vs 42.50\u00a0g\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.016), while the level of aspartate aminotransferase (AST) was higher (23\u00a0U\/L vs 18\u00a0U\/L, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). Abnormal results of liver blood tests in patients with COVID\u201019 included increased levels of alanine transaminase (ALT) (21.2%, 14 patients), AST (15.2%, 10 patients), and gamma\u2010glutamyl transpeptidase (GGT) (22.7%, 15 patients). After 5\u201010\u00a0days of treatment, levels of Alb and AST in COVID\u201019 patients were significantly decreased (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.027, respectively). Abnormal levels of Alb and AST in patients with COVID\u201019 were not associated with the liver condition (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). In addition, only levels of AST were positively correlated with the duration of hospital stay (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.334, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abnormal results of the liver blood test were found in COVID\u201019 patients. The COVID\u201019 patients on admission with the higher levels of AST might have longer hospital stays.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23391","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T05:24:52Z","timestamp":1591161892000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Elevated serum aspartate aminotransferase level identifies patients with coronavirus disease 2019 and predicts the length of hospital stay"],"prefix":"10.1002","volume":"34","author":[{"given":"Xuexiang","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University Huai\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University Huai\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xusheng","family":"An","sequence":"additional","affiliation":[{"name":"Intensive Care Unit The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University Huai\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shufeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Intensive Care Unit Huai'an Fourth People\u2019s Hospital Huai\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangnong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University Huai\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University Huai\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4761-0407","authenticated-orcid":false,"given":"Honggang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Affiliated Huaian No.1 People\u2019s Hospital of Nanjing Medical University Huai\u2019an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.https:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019. 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