{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:11:23Z","timestamp":1790687483713,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY19C080001"],"award-info":[{"award-number":["LY19C080001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The present study aimed to explore the association of long non\u2010coding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) with multiple myeloma (MM) risk and further investigate its correlation with clinical features, treatment response, survival profiles, and its interaction with microRNA\u2010125a (miR\u2010125a) in MM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally, 114 de novo symptomatic MM patients and 30 healthy donors (as controls) were recruited. Their bone marrow samples were collected before treatment (MM patients) and at enrollment (healthy donors), respectively. Subsequently, plasma cells were isolated from bone marrow for detection of lncRNA NEAT1 and miR\u2010125a expression via reverse transcription quantitative polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>lncRNA NEAT1 was upregulated in MM patients compared with healthy donors and presented with excellent value in distinguishing MM patients from healthy donors. In MM patients, lncRNA NEAT1 positively associated with International Staging System (ISS) stage, beta\u20102 microglobulin (\u03b22\u2010MG), and lactate dehydrogenase (LDH), but not correlated with core cytogenetics and other clinical features. Furthermore, lncRNA NEAT1 negatively associated with complete remission (CR), overall remission rate (ORR), progression\u2010free survival (PFS), and overall survival (OS). Moreover, lncRNA NEAT1 negatively associated with miR\u2010125a in MM patients. MiR\u2010125a was downregulated in MM patients compared with healthy donors, and it negatively associated with ISS stage, \u03b22\u2010MG, and LDH, but positively correlated with CR, ORR, PFS, and OS in MM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>lncRNA NEAT1 might interact with miR\u2010125a, and serves as a novel biomarker for treatment response and survival profiles in MM, indicating its clinical value for MM management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23399","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T11:51:51Z","timestamp":1593604311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long non\u2010coding RNA NEAT1 serves as a novel biomarker for treatment response and survival profiles via microRNA\u2010125a in multiple myeloma"],"prefix":"10.1002","volume":"34","author":[{"given":"Haifeng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Lymphatic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"},{"name":"Department of Lymphatic Medical Oncology Institute of Cancer and Basic Medicine\uff08IBMC\uff09 Chinese Academy of Sciences Hangzhou China"},{"name":"Department of Radiotherapy Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuailing","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Lymphatic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"},{"name":"Department of Lymphatic Medical Oncology Institute of Cancer and Basic Medicine\uff08IBMC\uff09 Chinese Academy of Sciences Hangzhou China"},{"name":"Department of Radiotherapy Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Lymphatic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"},{"name":"Department of Lymphatic Medical Oncology Institute of Cancer and Basic Medicine\uff08IBMC\uff09 Chinese Academy of Sciences Hangzhou China"},{"name":"Department of Radiotherapy Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiyun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Lymphatic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"},{"name":"Department of Lymphatic Medical Oncology Institute of Cancer and Basic Medicine\uff08IBMC\uff09 Chinese Academy of Sciences Hangzhou China"},{"name":"Department of Radiotherapy Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-9289","authenticated-orcid":false,"given":"Jialin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Lymphatic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"},{"name":"Department of Lymphatic Medical Oncology Institute of Cancer and Basic Medicine\uff08IBMC\uff09 Chinese Academy of Sciences Hangzhou China"},{"name":"Department of Radiotherapy Cancer Hospital of the University of Chinese Academy of Sciences\uff08Zhejiang Cancer Hospital\uff09 Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7]]},"reference":[{"issue":"27","key":"e_1_2_7_2_1","first-page":"470","article-title":"The diagnosis and treatment of multiple myeloma","volume":"113","author":"Gerecke C","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.31357"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12590"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24402"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0018-y"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13237"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-160221"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.12.070"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27393"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.01.003"},{"issue":"19","key":"e_1_2_7_13_1","first-page":"6403","article-title":"NEAT1 promotes cell proliferation in multiple myeloma by activating PI3K\/AKT pathway","volume":"22","author":"Xu H","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2019.10.026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29309"},{"issue":"2","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"e23056","DOI":"10.1002\/jcla.23056","article-title":"Long noncoding RNA NEAT1 correlates with higher disease risk, worse disease condition, decreased miR\u2010124 and miR\u2010125a and predicts poor recurrence\u2010free survival of acute ischemic stroke","volume":"34","author":"Li P","year":"2019","journal-title":"J Clin Lab Anal"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2033"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt297"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4135"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.119"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0542-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.03.023"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2006.21.4.639"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4274\/Tjh.2012.0044"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54407-4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09649-1"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8618-7_4"},{"issue":"2","key":"e_1_2_7_31_1","first-page":"e1529","article-title":"The miR\u2010125a and miR\u2010320c are potential tumor suppressor microRNAs epigenetically silenced by the polycomb repressive complex 2 in multiple myeloma","volume":"4","author":"Alzrigat M","year":"2017","journal-title":"RNA Dis"},{"issue":"4","key":"e_1_2_7_32_1","first-page":"2465","article-title":"miRNA\u2010125a modulates autophagy of thyroiditis through PI3K\/Akt\/mTOR signaling pathway","volume":"17","author":"Chen D","year":"2019","journal-title":"Exp Ther Med"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1509636"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjcla.23399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23399","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23399","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23399","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:57:12Z","timestamp":1696319832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/jcla.23399"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23399","archive":["Portico"],"relation":{},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23399"}}