{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:56:19Z","timestamp":1753869379208,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Numerous studies have assessed the association between <jats:italic>xeroderma pigmentosum complementation group C (XPC)<\/jats:italic> polymorphisms and susceptibility of prostate cancer (PCa); however, the findings remain inconsistent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an updated analysis utilizing data from electronic databases to obtain a more accurate estimation of the relationship between <jats:italic>XPC<\/jats:italic> rs2228001 A\/C polymorphism and PCa risk. We further used in silico tools to investigate this correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally, 5,305 PCa cases and 6,499 control subjects were evaluated. When all studies pooled together, we detected no positive result (recessive genetic model: OR\u00a0=\u00a01.14, 95% CI\u00a0=\u00a00.93\u20101.40, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u00a0=\u00a00.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.212); nevertheless, the <jats:italic>XPC<\/jats:italic> rs2228001 A\/C variant was associated with PCa risk in Asian descendants in the subgroup analysis (OR\u00a0=\u00a01.21, 95% CI\u00a0=\u00a01.01\u20101.43, <jats:italic>P<\/jats:italic><jats:sub>heterogeneity<\/jats:sub>\u00a0=\u00a00.008, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.034). In silico tools showed that more than 20 proteins can participate in the protein crosstalk with XPC. The expression of <jats:italic>XPC<\/jats:italic> was down\u2010regulated in all Gleason scores of prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study indicated that the <jats:italic>XPC<\/jats:italic> rs2228001 A\/C variant may be associated with elevated PCa risk in Asian patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23403","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T05:29:06Z","timestamp":1591162146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of <i>Xeroderma pigmentosum group C<\/i> polymorphism on the likelihood of prostate cancer"],"prefix":"10.1002","volume":"34","author":[{"given":"Yidan","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Oncology Affiliated Hospital of Jiangnan University Wuxi 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