{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:20:16Z","timestamp":1790713216919,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["QML20180502"],"award-info":[{"award-number":["QML20180502"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore the characteristics of coagulase\u2010negative<jats:italic>Staphylococci<\/jats:italic>other than<jats:italic>Staphylococci epidermidis<\/jats:italic>(Nse\u2010CoNS) meningitis and to apply cerebrospinal fluid (CSF) times to positivity culture (TTPC) for the precise differentiation of meningitis from contamination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a case\u2010control study to accomplish the following: First, we retrospectively reviewed records of post\u2010neurosurgical patients\u2019 CSF that yielded Nse\u2010CoNS from January to October 2019 at the Beijing Tiantan Hospital; 17 clinical and 12 laboratory characteristics were reviewed. Second, we investigated the TTPC of the Nse\u2010CoNS, the cutoffs, and corresponding parameters to differentiate Nse\u2010CoNS meningitis from contamination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, a total of 146 patients with Nse\u2010CoNS CSF culture positive were enrolled. The average TTPC in the Nse\u2010CoNS meningitis group was significantly shorter than in the contamination group (20.2\u00a0\u00b1\u00a05.0\u00a0hours and 30.2\u00a0\u00b1\u00a012.6\u00a0hours, respectively,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The area under curve (AUC) of the model was 0.802. A TTPC of 20.0\u00a0hours had 94.3% sensitivity and a negative value of 90.2% for predicting Nse\u2010CoNS meningitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nse\u2010CoNS meningitis often causes confusion in clinical diagnosis. In this study, we evaluated the clinical predictive factors of Nse\u2010CoNS meningitis and confirmed that the median TTPC in the Nse\u2010CoNS meningitis group was significantly shorter than in the contamination group. A TTPC shorter than 20.0\u00a0hours was associated with Nse\u2010CoNS meningitis, while a TTPC longer than 20.0\u00a0hours was associated with Nse\u2010CoNS contamination. This information will be helpful for the rapid diagnosis of Nse\u2010CoNS meningitis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23447","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T06:14:04Z","timestamp":1594188844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Time to positive culture can differentiate post\u2010neurosurgical coagulase\u2010negative<i>Staphylococci<\/i>other than<i>S epidermidis<\/i>meningitis from contamination: A case\u2010control observational study"],"prefix":"10.1002","volume":"34","author":[{"given":"Guanghui","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital and Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Diagnosis Laboratory of Beijing Tiantan Hospital and Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Diagnostics Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Diagnostics Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Diagnostics Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Diagnostics Capital Medical University Beijing 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