{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:11:31Z","timestamp":1780056691430,"version":"3.54.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81871736"],"award-info":[{"award-number":["NSFC 81871736"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802076"],"award-info":[{"award-number":["81802076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have assessed the sensitization of mycotic allergens and <jats:italic>Aspergillus fumigatus<\/jats:italic> molecular allergens. This study aimed to investigate the relationships of <jats:italic>A fumigatus<\/jats:italic> components and mycotic allergens in allergic bronchopulmonary aspergillosis (ABPA) patients and <jats:italic>A fumigatus<\/jats:italic> (Af)\u2010sensitized asthma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum sIgE levels of <jats:italic>Penicillium chrysogenum<\/jats:italic>, <jats:italic>Cladosporium herbarum<\/jats:italic>, <jats:italic>Mucor racemosus<\/jats:italic>, <jats:italic>Candida albicans<\/jats:italic>, <jats:italic>Alternaria alternata<\/jats:italic>, <jats:italic>Helminthosporium halodes,<\/jats:italic> and <jats:italic>A fumigatus<\/jats:italic> allergen components (Asp f 1, Asp f 2, Asp f 3, Asp f 4, and Asp f 6) were measured via the ImmunoCAP assay in 18 ABPA and 54 Af\u2010sensitized asthma patients in Guangzhou city, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>94.44% of ABPA patients and 87.04% of Af\u2010sensitized asthma patients were co\u2010sensitized to at least one other fungal allergen. The positive rates of Asp f 1 (88.89% vs 59.26%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), Asp f 2 (66.67% vs 33.33%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), Asp f 4 (61.11% vs 33.33%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), and Asp f 6 (66.67% vs 14.81%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) in ABPA patients were higher than those in Af\u2010sensitized asthma patients. IgE levels of Asp f 1 (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>.05), Asp f 4 (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>.05), and Asp f 6 (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>.001) were higher in ABPA patients than in Af\u2010sensitized asthma patients. Optimal scale analysis showed that ABPA was more relevant to Af components (Cronbach's alpha\u00a0=\u00a090.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:italic>A fumigatus<\/jats:italic> components and their relationships with various mycotic allergens were different in ABPA and Af\u2010sensitized asthma patients. This finding may help local doctors in the diagnosis and immunotherapy of fungal allergies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23448","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T10:09:21Z","timestamp":1593684561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Molecular allergen sensitization of <i>Aspergillus fumigatus<\/i> between allergic bronchopulmonary aspergillosis and <i>A\u00a0fumigatus<\/i>\u2010sensitized asthma in Guangzhou, Southern China"],"prefix":"10.1002","volume":"34","author":[{"given":"Wenting","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nili","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunology Guangzhou Kingmed Diagnostics Group Co., Ltd. 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