{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:07:07Z","timestamp":1785337627039,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2020jscx\u2010fyzx0230"],"award-info":[{"award-number":["cstc2020jscx\u2010fyzx0230"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670071"],"award-info":[{"award-number":["81670071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine the diagnostic value of hematologic markers for coronavirus disease 2019 (COVID\u201019) and explore their relationship with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects included 190 COVID\u201019 patients, 190 healthy subjects, and 105 influenza pneumonia (IP) patients. COVID\u201019 patients were divided into the ARDS and non\u2010ARDS groups. Routine blood examination, biochemistry indicator, days in hospital, body temperature, pneumonia severity index (PSI), CURB\u201065, and MuLBSTA were recorded. Correlations between variables were assessed using Spearman's correlation analysis. Receiver operating characteristic (ROC) curves were used to study the accuracy of the various diagnostic tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy subjects, COVID\u201019 patients had lower white blood cell (WBC), lymphocyte, platelet, and hemoglobin levels; higher percentages of neutrophils and monocytes; lower percentages of lymphocytes and higher neutrophil\u2010to\u2010lymphocyte ratio (NLR), monocyte\u2010to\u2010lymphocyte ratio (MLR), and platelet\u2010to\u2010lymphocyte ratio (PLR) values (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). COVID\u201019 patients had higher WBC and neutrophil levels and lower percentages of lymphocytes compared to IP (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). ROC curve analysis revealed that MLR had a high diagnostic value in differentiating COVID\u201019 patients from healthy subjects, but not from IP patients. NLR showed significant positive correlations with PSI, CURB\u201065, and MuLBSTA. Lymphocyte count was lower in the ARDS group and yielded a higher diagnostic value than the other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Monocyte\u2010to\u2010lymphocyte ratio showed an acceptable efficiency to separate COVID\u201019 patients from healthy subjects, but failed to rule out IP patients. NLR may be a reliable marker to evaluate the disease severity of COVID\u201019. Lymphocyte count may be useful to establish the early diagnosis of ARDS in the COVID\u201019 patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23475","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T05:30:07Z","timestamp":1595050207000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Diagnostic value of peripheral hematologic markers for coronavirus disease 2019 (COVID\u201019): A multicenter, cross\u2010sectional study"],"prefix":"10.1002","volume":"34","author":[{"given":"Junnan","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Chongqing Public Health Medical Center  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Mei","sequence":"additional","affiliation":[{"name":"Health Management Center The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Infectious Medicine Qianjiang Central Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-3650","authenticated-orcid":false,"given":"Daoxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taaa011"},{"key":"e_1_2_10_4_1","unstructured":"World Health Organization.Coronavirus Disease (COVID\u201019) Outbreak.https:\/\/www.who.int. 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