{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:58:07Z","timestamp":1788274687870,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The development and progression of hepatitis B virus\u2010related decompensated cirrhosis (DeCi) is associated with inflammatory responses. The monocyte\u2010to\u2010lymphocyte ratio (MLR), neutrophil\u2010to\u2010lymphocyte ratio (NLR), and red cell distribution width (RDW) are well\u2010known inflammation markers. We aimed to assess the utility of these parameters for predicating the prognosis of patients with HBV\u2010DeCi.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively recruited 174 patients diagnosed with HBV\u2010DeCi. Univariate and multivariate regression models were used to determine risk factors for mortality. Areas under the receiver operating characteristic curves were calculated to estimate and compare the predictive values of the three parameters. Hepatic function was evaluated using the Model for End\u2010Stage Liver Disease (MELD) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The NLR, RDW, and MLR were found to be significantly higher in patients who did not survive compared with surviving patients. Moreover, these variables were all able to predict early poor outcomes in patients with HBV\u2010DeCi, with NLR exhibiting the highest accuracy. Furthermore, a combination of the NLR and MELD score was a more accurate prognostic marker for predicting mortality than either marker alone in such patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hematological parameters can provide prognostic information for patients with HBV\u2010DeCi. Routine assessment of these parameters at admission may provide valuable data to complement other conventional measures for assessing disease condition in patients with HBV\u2010DeCi.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23478","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T05:25:59Z","timestamp":1594790759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluation of the neutrophil\u2010to\u2010lymphocyte ratio, monocyte\u2010to\u2010lymphocyte ratio, and red cell distribution width for the prediction of prognosis of patients with hepatitis B virus\u2010related decompensated cirrhosis"],"prefix":"10.1002","volume":"34","author":[{"given":"XinKe","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology College of Medicine The First Affiliated Hospital Zhejiang University Hangzhou 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