{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:26Z","timestamp":1772118686083,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Early diagnosis is very important to improve the survival rate of patients with gastric cancer (GC), especially in asymptomatic participants. However, low sensitivity of common biomarkers has caused difficulties in early screening of GC. In this study, we explored whether MIC\u20101 can improve the detection rate of early GC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We screened 8257 participants based on risk factors such as age, gender, and family history for physical examination including gastroscopy. Participant blood samples were taken for measure MIC\u20101, CA\u2010199, CA72\u20104, and PG1\/PG2 levels. The diagnostic performance of MIC\u20101 was assessed and compared with CA\u2010199, CA72\u20104, and PG1\/PG2, and its role in early GC diagnosis and the assessment of the risk of precancerous lesions have also been studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Based on endoscopic and histopathological findings, 55 participants had GC, 566 participants had low\u2010grade neoplasia, and 2605 participants had chronic gastritis. MIC\u20101 levels were significantly elevated in GC serum samples as compared to controls (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The sensitivity of serum MIC\u20101 for GC diagnosis was much higher than that of CA\u2010199 (49.1% vs 20.0%) with similar specificities. Moreover, receiver operating characteristic (ROC) curve analysis also showed that serum MIC\u20101 had a better performance compared with CA\u2010199, CA72\u20104, and PG1\/PG2 in distinguishing early\u2010stage GC (AUC: 72.9% vs 69.5%, 67.5%, 44.0%, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serum MIC\u20101 is significantly elevated in most patients with early GC. MIC\u20101 can serve as a novel diagnostic marker of early GC and value the risk of GC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23568","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T21:49:15Z","timestamp":1611870555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Diagnostic value of macrophage inhibitory cytokine 1 as a novel prognostic biomarkers for early gastric cancer screening"],"prefix":"10.1002","volume":"35","author":[{"given":"Xin","family":"Ge","sequence":"first","affiliation":[{"name":"Department of Laboratory Diagnostics The First Affiliated Hospital of University of Science and Technology of China Hefei P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics The First Affiliated Hospital of University of Science and Technology of China Hefei P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanling","family":"Ma","sequence":"additional","affiliation":[{"name":"Anhui Office for Cancer Control and Research The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics The First Affiliated Hospital of University of Science and Technology of China Hefei P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaowu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics The First Affiliated Hospital of University of Science and Technology of China Hefei P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-034X","authenticated-orcid":false,"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Diagnostics The First Affiliated Hospital of University of Science and Technology of China Hefei P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i37.10510"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i38.13842"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2012.12.007"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-199708000-00005"},{"issue":"2018","key":"e_1_2_11_8_1","first-page":"1024074","article-title":"Screening biomarker as an alternative to endoscopy for the detection of early gastric cancer: the combination of serum trefoil factor family 3 and pepsinogen","volume":"9","author":"Lee HS","year":"2018","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-013-0259-5"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2014.07.034"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.21.11514"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0165"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.189052"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-170792"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn031"},{"issue":"15","key":"e_1_2_11_16_1","first-page":"4648","article-title":"Macrophage inhibitory cytokine\u20101 induces the invasiveness of gastric cancer cells by up\u2010regulating the urokinase\u2010type plasminogen activator system","volume":"63","author":"Lee DH","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12331"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21919"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.22.13760"},{"key":"e_1_2_11_20_1","first-page":"4648","article-title":"Macrophage inhibitory cytokine\u20101 induces the invasiveness of gastric cancer cells by up\u2010regulating the urokinase\u2010type plasminogen activator system [J]","volume":"63","author":"Lee DH","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01994.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.12.008"}],"container-title":["Journal of Clinical Laboratory Analysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23568","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jcla.23568","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jcla.23568","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T09:35:38Z","timestamp":1693733738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jcla.23568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,12]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1002\/jcla.23568"],"URL":"https:\/\/doi.org\/10.1002\/jcla.23568","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-17962\/v1","asserted-by":"object"}]},"ISSN":["0887-8013","1098-2825"],"issn-type":[{"value":"0887-8013","type":"print"},{"value":"1098-2825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,12]]},"assertion":[{"value":"2020-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23568"}}