{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:21:19Z","timestamp":1785338479337,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T00:00:00Z","timestamp":1602374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Under conditions of oxidative stress, hydroxyl radicals can oxidize phenylalanine (Phe) into various tyrosine (Tyr) isomers (meta\u2010, ortho\u2010, and para\u2010tyrosine; m\u2010, o\u2010, and p\u2010Tyr), depending on the location of the hydroxyl group on the oxidized benzyl ring. This study aimed to compare patients with ST\u2010segment elevation myocardial infarction (STEMI) and non\u2010STEMI (NSTEMI) and the serum levels of Phe and Tyr isomers at the aortic root and distal to the culprit lesion in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010four patients participated in the study: 23 with STEMI and 21 with NSTEMI. Arterial blood samples were taken from the aortic root through a guiding catheter and from the culprit vessel segment distal from the primary lesion with an aspiration catheter, during the percutaneous coronary intervention. Serum levels of Phe, p\u2010Tyr, m\u2010Tyr, and o\u2010Tyr were determined using reverse\u2010phase high\u2010performance liquid chromatography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum levels of Phe were significantly higher distal to the culprit lesion compared to the aortic root in patients with STEMI. Serum p\u2010Tyr\/Phe and m\u2010Tyr\/Phe concentration ratios were both lower distal to the culprit lesion than at the aortic root in patients with STEMI. There were no statistically significant differences with respect to changes in serum Phe and Tyr isomers distal to the culprit lesion compared to the aortic root in patients with NSTEMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data suggest that changes in serum levels of different Tyr isomers can mediate the effects of oxidative stress during myocardial infarction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23613","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T01:19:44Z","timestamp":1602465584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of serum phenylalanine and tyrosine isomers in patients with ST\u2010segment elevation vs non\u2010ST\u2010segment elevation myocardial infarction"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4602-6663","authenticated-orcid":false,"given":"Ied","family":"Al\u2010Sadoon","sequence":"first","affiliation":[{"name":"Doctoral School of Health Sciences Faculty of Health Science University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Department of Medicine and Nephrological Center Medical School University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilard","family":"Kun","sequence":"additional","affiliation":[{"name":"Department of Medicine and Nephrological Center Medical School University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e9desz","family":"Ahmann","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences Faculty of Health Science University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attila","family":"Konyi","sequence":"additional","affiliation":[{"name":"Heart Institute Medical School University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"Verz\u00e1r","sequence":"additional","affiliation":[{"name":"Doctoral School of Health Sciences Faculty of Health Science University of P\u00e9cs P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/84.10.917"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_117_17"},{"key":"e_1_2_6_4_1","first-page":"381","article-title":"Atherosclerosis and oxidative stress","volume":"23","author":"Bonomini F","year":"2008","journal-title":"Histol 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