{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:00:12Z","timestamp":1791140412298,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate the role of Tp\u2010e and (Tp\u2010e)\/QT ratio in differentiating benign ventricular premature complex (VPC) and malignant polymorphic ventricular tachycardia (PVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2017 to December 2017, patients with documented polymorphic ventricular tachycardia (PVT) or ventricular fibrillation (VF) were consecutive included and classified as PVT\/VF group. Sixty age\u2010 and sex\u2010matched healthy individuals were recruited as comparative control and subdivided into non\u2010VPC and VPC group. Clinical characteristics and Tp\u2010e and Tp\u2010e\/QT ratio between the three groups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Tp\u2010e and (Tp\u2010e)\/QT ratio were significantly higher in patients of PVT\/VF group compared with the other two groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Episodes of syncope were more frequent in patients with PVT\/VF (\n                      <jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>\n                      .05). The sensitivity and specificity of a Tp\u2010e interval \u226586\u00a0ms for malignant arrhythmias triggered by VPCs were 88% and 66%, respectively, while the sensitivity and specificity of the Tp\u2010e\/QT ratio \u22650.24 were 82% and 70%, respectively. Five patients complained recurrence of syncope in the PVT\/VF group and 1 patient died with mean follow\u2010up of 18\u00a0months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tp\u2010e interval and the Tp\u2010Te\/QT ratio is significantly increased in patients with PVT\/VF and may be used as a novel non\u2010invasive marker of differentiating malignant and benign VPC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23636","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T05:16:00Z","timestamp":1608268560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Tp\u2010e and (Tp\u2010e)\/QT ratio as a non\u2010invasive risk factors for malignant ventricular arrhythmia in patients with idiopathic ventricular premature complexes"],"prefix":"10.1002","volume":"35","author":[{"given":"Donghua","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zhaoqing City Zhaoqing City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zhaoqing City Zhaoqing City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The First People's Hospital of Zhaoqing City Zhaoqing City 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