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Currently, research investigating tissue engineering of the larynx is either ongoing or in the preclinical trial stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search was performed on the Advanced search field of PubMed using the keywords: \u201c(laryncheal tissue engineering) AND (cartilage regeneration OR scaffolds OR stem cells OR biomolecules).\u201d After applying the selection criteria, 65 articles were included in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The present review focuses on the rapidly expanding field of tissue\u2010engineered larynx, which aims to provide stem cell\u2013based scaffolds combined with biological active factors such as growth factors for larynx reconstruction and regeneration. The trend in recent studies is to use new techniques for scaffold construction, such as 3D printing, are developed. All of these strategies have been instrumental in guiding optimization of the tissue\u2010engineered larynx, leading to a level of clinical induction beyond the in vivo animal experimental phase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review summarizes the current progress and outlines the necessary basic components of regenerative laryngeal medicine in preclinical fields. Finally, it considers the design of scaffolds, support of growth factors, and cell therapies toward potential clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23646","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T20:30:49Z","timestamp":1608409849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tissue engineering of the larynx: A contemporary review"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-8494","authenticated-orcid":false,"given":"Jingjing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery Lihuili Hospital Ningbo University Ningbo 315040 China"},{"name":"Department of Otorhinolaryngology\u2013 Head and Neck Surgery The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 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