{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:13:47Z","timestamp":1790284427502,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:00:00Z","timestamp":1606003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate the ability of peripheral blood inflammatory markers in predicating the typing of COVID\u201019, prognosis, and some differences between COVID\u201019 and influenza A patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data on 285 cases laboratory\u2010confirmed as SARS\u2010CoV\u20102 infection were obtained from a Wuhan local hospital's electronic medical records according to previously designed standardized data collection forms. Additional 446 Influenza A outpatients\u2019 hematologic data were enrolled for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NLR, SII, RLR, PLR, HsCRP, and IL\u20106 were significant higher and LMR was lower in severe COVID\u201019 patients than in mild COVID\u201019 patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). PLR and LMR were lower in the individuals with influenza A than those with COVID\u201019 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). COVID\u201019 patients with higher levels of NLR, SII, RLR, PLR, HsCRP, and IL\u20106 and lower LMR were significantly associated with the severe type. AUC of NLR (0.76) was larger while the specificity of IL\u20106 (86%) and sensitivity of HsCRP (89%) were higher than other inflammatory markers in predicating the typing of COVID\u201019. PT had obvious correlation with all the inflammatory markers except RPR. NLR showed positive correlations with AST, TP, BUN, CREA, PT, and D\u2010dimer. Patients with high IL\u20106 levels have a relatively worse prognosis (HR\u00a0=\u00a02.30).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peripheral blood inflammatory markers reflected the intensity of inflammation and associated with severity of COVID\u201019.NLR was more useful to predict severity as well as IL\u20106 to predict prognosis of COVID\u201019. PLR and LMR were initially found to be higher in SARS\u2010CoV\u20102 virus\u2010infected group than in influenza A.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23657","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T02:59:45Z","timestamp":1606100385000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Peripheral blood inflammatory markers in predicting prognosis in patients with COVID\u201019. 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