{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T14:28:25Z","timestamp":1783348105888,"version":"3.54.6"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Lymphocyte count\n                      <jats:bold>(<\/jats:bold>\n                      LYM) of peripheral blood and some indices of general biochemical analysis had diagnostic and prognostic value for coronavirus disease 2019 (COVID\u201019), and the value of other remaining indices is rare.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 94 patients with COVID\u201019 were enrolled at Renmin Hospital of Wuhan University. According to the severity of COVID\u201019, the patients were divided into three groups (moderate 49, severe 35, and critical 10), and 40 healthy cases were enrolled in the same period as healthy controls. The diagnostic and prognostic value of indices in peripheral blood cell count and general biochemical analysis was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with healthy cases, the value differences in peripheral blood analysis in patients with COVID\u201019 were statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), the differences in LYM, neutrophil count (Neu), platelet count (PLT), and white blood cell count (WBC) were statistically significant among different severity of COVID\u201019 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Compared with healthy cases, the differences in general biochemical results in patients with COVID\u201019 were statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01), the value differences in direct bilirubin (DBIL), low\u2010density lipoprotein cholesterol (LDL\u2010Ch), and nitrogen (urea) were statistically significant among different severity of COVID\u201019 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). Neutrophil\/lymphocyte ratio (NLR) had higher sensitivity and specificity for COVID\u201019 diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Some indices of peripheral blood cell count and general biochemical analysis were valuable in discriminating COVID\u201019 and predicting severity and adverse outcome of patients with COVID\u201019. For clinician, it is better to use more economical and easy\u2010to\u2010get indices to diagnose and predict the prognosis of COVID\u201019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jcla.23668","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T04:33:49Z","timestamp":1607920429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The prognostic value of general laboratory testing in patients with COVID\u201019"],"prefix":"10.1002","volume":"35","author":[{"given":"Zhihua","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Wuhan Fourth Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghua","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Wuhan University School of Basic Medical Sciences Wuhan China"},{"name":"Hubei Province Key Laboratory of Allergy and Immunology School of Basic Medical Sciences Wuhan University Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Chen","sequence":"additional","affiliation":[{"name":"Hubei Province Key Laboratory of Allergy and Immunology School of Basic Medical Sciences Wuhan University Wuhan China"},{"name":"Department of Immunology Wuhan University School of Basic Medical Sciences Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1676-3235","authenticated-orcid":false,"given":"Qingfeng","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Liyuan Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shanghai Gongli Hospital The Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_10_3_1","unstructured":"Coronavirus disease (COVID\u20102019) situation reports.https:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019\/situation\u2010reports. 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