{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:41:22Z","timestamp":1768736482025,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Objective measures used for the differential diagnosis and severity assessment of allergic rhinitis (AR) are still lacking. The involvement of hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) in the development of AR indicates that nasal exhaled H<jats:sub>2<\/jats:sub>S (NeH<jats:sub>2<\/jats:sub>S) has potential as a biomarker to be used in AR patients. This study aimed to evaluate the application value of NeH<jats:sub>2<\/jats:sub>S measurement in the diagnosis and assessment of AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a multi\u2010center cross\u2010sectional survey conducted in Northwestern China. Demographic information collection and rhinitis assessment were completed through questionnaires. The level of NeH<jats:sub>2<\/jats:sub>S and serum immunoglobulin E were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The level of NeH<jats:sub>2<\/jats:sub>S in general population ranged from 0 to 35\u00a0ppb, with a median value of 2\u00a0ppb. The NeH<jats:sub>2<\/jats:sub>S levels in seasonal allergic rhinitis (SAR) patients were significantly lower than those in general population (2 [1, 2.75] vs. 2 [2, 3] ppb;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.023), and the NeH<jats:sub>2<\/jats:sub>S value of the SAR group tended to be lower than that of the non\u2010allergic rhinitis (NAR) group (2 [1, 2.75] vs. 2 [2, 3] ppb;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.094). The subgroup of AR patients with symptoms lasting longer than 2\u00a0weeks per month had a lower NeH<jats:sub>2<\/jats:sub>S level compared with the subgroup of patients with symptoms lasting less than 2\u00a0weeks per month (2 [1, 2] vs. 2 [2, 3] ppb;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study described the distribution range of NeH<jats:sub>2<\/jats:sub>S levels in the general population. Further study with larger sample size was needed to clarify the relationship between NeH<jats:sub>2<\/jats:sub>S level and AR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23678","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T06:35:58Z","timestamp":1607409358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Levels of nasal exhaled hydrogen sulfide in the general population and allergic rhinitis patients"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1171-1858","authenticated-orcid":false,"given":"Lisha","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases Department of Allergy Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College National Clinical Research Center for Dermatologic and Immunologic Diseases Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonglin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shenmu Hospital Shenmu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shenmu Hospital Shenmu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixi","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases Department of Allergy Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; 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