{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:29:50Z","timestamp":1778513390814,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Laboratory Analysis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the present study was to investigate the expression profiles of circular RNAs (circRNAs) in the pericystic tissue of patients with cystic echinococcosis (CE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>CircRNA expression profiles were obtained by circRNA microarray of four matched pairs of pericystic tissues affected by CE and adjacent normal liver tissues. qRT\u2010PCR was used to validate the differential expression of some circRNAs identified by the microarray analysis. The potential functions of the differentially expressed circRNAs in the CE pericystic tissues were predicted by bioinformatic analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the adjacent normal liver tissues, 177 circRNAs were upregulated and 166 circRNAs were downregulated in CE pericystic tissues based on a \u22652.0\u2010fold change. The top 10 upregulated circRNAs were hsa_circRNA_001654,hsa_circRNA_103361,hsa_circRNA_001490,hsa_circRNA_104310,hsa_circRNA_100395,hsa_circRNA_102485,hsa_circRNA_001459,hsa_circRNA_104193,hsa_circRNA_400043, and hsa_circRNA_006773; The top 10 downregulated circRNAs were hsa_circRNA_400633,hsa_circRNA_404974,hsa_circRNA_068482 ,hsa_circRNA_100974,hsa_circRNA_049637,hsa_circRNA_404798,hsa_circRNA_400064,hsa_circRNA_004045,hsa_circRNA_101379, and hsa_circRNA_016771;The circRNA\u2010seq results for 15 selected differentially expressed circRNAs were validated by qRT\u2010PCR. The qRT\u2010PCR analysis showed that hsa_circRNA_006773, hsa_circRNA_049637, hsa_circRNA_104349, and hsa_circRNA_406281 were differentially expressed in CE pericystic tissues when compared with their expression in the adjacent normal liver tissues. Interestingly, 319 miRNAs and 52 mRNAs were predicted to be adsorbed by these four differentially expressed circRNAs. Gene Ontology analysis revealed that these circRNAs may be involved in the response to organic cyclic compounds and endogenous stimuli and in cellular organismal processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Differential expression of circRNAs may be associated with the development and progression of CE, and these circRNAs might be useful as biomarkers for prognosis prediction and as treatment targets.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jcla.23687","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T22:41:09Z","timestamp":1610318469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Expression profile of circular RNAs in cystic echinococcosis pericystic tissue"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4781-5859","authenticated-orcid":false,"given":"Baheti","family":"Kalifu","sequence":"first","affiliation":[{"name":"Xinjiang Medical University Urumqi Xinjiang Uygur Autonomous Region China"},{"name":"Department of Vascular and Hepatobilliry Surgery People's Hospital of Xinjiang Uygur Autonomous Region Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abulaihaiti","family":"Maitiseyiti","sequence":"additional","affiliation":[{"name":"Department of Vascular and Hepatobilliry Surgery People's Hospital of Xinjiang Uygur Autonomous Region Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohu","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Vascular and Hepatobilliry Surgery People's Hospital of Xinjiang Uygur Autonomous Region Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University Urumqi Xinjiang Uygur Autonomous Region China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Vascular and Hepatobilliry Surgery People's Hospital of Xinjiang Uygur Autonomous Region Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apar.2016.11.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2014066"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70134-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.12-0692"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.139.2.7220891"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14573-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(12)60035-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-014-0610-7"},{"key":"e_1_2_6_10_1","first-page":"276","article-title":"The new aspects in recognition of pathogenesis of the pericyst of human hepatic Echinococcus granulosus","volume":"13","author":"Peng XY","year":"2005","journal-title":"World Chin J Digestol"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i5.1377"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2006.08.013"},{"issue":"4","key":"e_1_2_6_13_1","first-page":"297","article-title":"A synchronous occurrence of hepatocellular carcinoma and echinoccocal liver cyst \u2010 can parasite promote carcinogenesis? 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